Oral liquid antidepressant solution

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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Details

514213, 514215, 514922, 514970, 514973, 514994, A01N 4346, A61K 3155

Patent

active

060403012

ABSTRACT:
For the oral administration of the anti-depressant mirtazapine an aqueous solution or suspension is found which is preferably stabilized by methionine, is thickened, and which has a pH of from 2.5 to 3. By the formulation according to the invention, an undesirable local anesthetic effect of mirtazapine is avoided.

REFERENCES:
patent: 4062848 (1977-12-01), van der Burg
patent: 5208261 (1993-05-01), Van Den Oetelaar et al.
patent: 5238688 (1993-08-01), Beuving et al.
Davis R et al., Mirtazapine A Review of its Pharmacology and Therapeutic Potential in the Management of Major Depression, vol. 5, No. 2, May 1, 1996,. pp. 389-402.
Mattila M et al., Actions and Interactions of Psychotropic Drugs on Human Performance and Mood: Single Doses or Org 3770, Amitriptyline, and Diazepam, Pharmacology and Toxicology, vol. 65, No. 2, Aug. 1, 1989, pp. 81-88.

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