Oral immunization by transgenic plants

Details Oral immunization by transgenic plants Oral immunization by transgenic plants

1995-06-01

1997-08-05

Moody, Patricia R.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 693, 4352523, 4353201, 536 237, 800205, 424 937, 4242341, 424439, 935 65, 935 67, C12N 1531, C12N 510, A01H 500, A61K 3902

Patent

active

056541848

ABSTRACT:
The invention is directed to transgenic plants expressing colonization and/or virulence antigens specified by genes from pathogenic microorganisms. It is also directed to the use of such transgenic plants for oral immunization of humans and other animals to elicit a secretory immune response which inhibits colonization of or invasion by such pathogenic microorganisms through a mucosal surface of humans or other animals.

REFERENCES:
patent: 4771002 (1988-09-01), Gelvin
patent: 4774182 (1988-09-01), Syzbalski
patent: 4784949 (1988-11-01), Gelfand
patent: 4894332 (1990-01-01), Schaller et al.
Kovgan, A.A., V.M. Zhdanov (1989) "Potential vector for introducing animal virus genes into cells of higher plants" Biotekhnologiya 5(2):148-154, **abstract No. 207160n, Chemical Abstracts 110:225.
Aizpurua et al 1988 (Feb.) J. Exp. Med. 167: 440-451.
Clements et al 1986 Infection and Immunity 53: 685-692.
Dallas et al 1980 Nature 288: 499-501.
Holt et al 1982 Infection and Immunity 38: 147-156.

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