Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-11-01
1997-06-24
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514360, 514364, 548122, 548129, 548132, 548143, 548235, C07D41310
Patent
active
056417969
ABSTRACT:
Antihyperglycemic compounds selected from the group consisting of C-substituted pentacycloazoles and N-alkyl-substituted pentacycloazoles.
REFERENCES:
patent: 4703052 (1987-10-01), Eggler et al.
patent: 4753956 (1988-06-01), Schnur
patent: 4791125 (1988-12-01), Clark
patent: 4912095 (1990-03-01), Kane et al.
patent: 4962119 (1990-10-01), Boschelli et al.
patent: 5037842 (1991-08-01), Goldstein
patent: 5066662 (1991-11-01), Hobbs et al.
patent: 5130379 (1992-07-01), Clark et al.
patent: 5155122 (1992-10-01), Connor et al.
patent: 5183825 (1993-02-01), Kees
patent: 5185353 (1993-02-01), Turnbull et al.
patent: 5239080 (1993-08-01), Sohda et al.
patent: 5254576 (1993-10-01), Romine et al.
patent: 5334604 (1994-08-01), Goldstein et al.
patent: 5376670 (1994-12-01), Connor et al.
Mullican et al., "Design of 5-(3,5-Di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as Orally-Active, Nonuclerogenic Antiinflammatory Agents", J. Med. Chem., 36, 1090-1099, (1993).
Momose et al., "Studies on Antidiabetic Agents. Synthesis and Biological Activities of Pioglitazone and Related Compounds", Chem. Pharm. Bull., 39(6) 1440-1445, (1991).
Sohda et al., "Studies on Antibiabetic Agents. Synthesis of 5-[4-(1-Methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione (ADD-3878) and Its Derivatives", Chem. Pharm. Bull., 30(10) 3580-3600, (1982).
Boschelli et al., "1,3,4-Oxadiazole, 1,3,4-Thiadiazole, and 1,2,4-Triazole Analogs of the Fenamates: In Vitro Inhibition of Cyclooxygenase and 5-Lipoxygenase Activities", J. Med. Chem., 93, 1802-1810, (1993).
Ellingboe et al., "Antihyperglycemic Activity of Novel Substituted 3H-1,2,3,5-Oxathiadiazole 2-Oxides", J. Med. Chem., 35, 1176-1183, (1992).
Ellingboe et al., "Antihyperglycemic Activity of Novel Naphthalenyl 3H-1,2,3,5-Oxathiadiazole 2-Oxides", J. Med. Chem., 36, 2485-2493, (1993).
Unangst et al., "Novel 1,2,4-Oxadiazoles and 1,2,4-Thiadiazoles as Dual 5-Lipoxygenase and Cyclooxygenase Inhibitors", J. Med. Chem., 35 3691-3698 (1992).
Gill et al., "Effects of Ciglitazone on Endogenous Plasma Islet Amyloid Polypeptide and Insulin Sensitivity in Obese-Diabetic Viable Yellow Mice", Life Sciences, vol. 48, No. 7, 703-710 (1991).
Girges et al., "Potentially Active Hypoglycemic Agents from N.sup.1 -Nicotinoyl-2-pyrazoline-5-one Derivatives and Their N.sup.1 -(Oxynictinoyl) Analogues", Stoffwechsel-Therapeutika Metabolism Therapeutics, Arzneim-Forsch Drug Res. 42 (II), Nr. 11, pp. 1350-1353 (1992).
Dow et al., "Benzyloxazolidine-2,4-diones as Potent Hypoglycemic Agents", J. Med. Chem., 34(5), 1538-1544 (1991).
Hulin et al., "Novel Thiazolidine-2,4-diones as Potent Euglycemic Agents", J. Med. Chem., 35, 1853-1864 (1992).
Zask et al., "Synthesis and Antihyperglycemic Activity of Novel 5-(Naphthalenylsulfonyl)-2,4-thiazolidinediones", J. Med. Chem., 33(5), 1418-1423 (1990).
Sohda et al., "Studies on Antidiabetic Agents. Novel Thiazolidinedione Derivatives as Potent Hypoglycemic and Hypolipidemic Agents", J. Med. Chem., 35(14) (1992).
Kees et al., "Perfluorocarbon-Based Antidiabetic Agents", J. Med. Chem., 35(5) (1992).
Clark et al., "Substituted Dihydrobenzopyran and Dihydrobenzofuran Thiazolidine-2,4-diones as Hypoglycemic Agents", J. Med. Chem., 34(1) (1991).
Dominianni Samuel J.
Fitch Lora L.
Schmiegel Klaus K.
Benjamin Roger S.
Boone David E.
Daus Donald G.
Eli Lilly and Company
Maciak Ronald S.
LandOfFree
Oral hypoglycemic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oral hypoglycemic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral hypoglycemic agents will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-149487