Drug – bio-affecting and body treating compositions – Dentifrices – Fluorine or fluorine compound containing
Patent
1992-09-09
1994-01-18
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
Fluorine or fluorine compound containing
424 49, 424 54, A61K 716, A61K 718, A61K 722
Patent
active
052798143
DESCRIPTION:
BRIEF SUMMARY
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates to oral and dental hygiene preparations which contain a combination of water-soluble fluorine compounds and phosvitin for protection against demineralization of the enamel.
2. Statement of Related Art
Oral and dental hygiene preparations are products which are used to clean and take care of the mouth, teeth and throat. In addition to the elimination of halitosis and the removal of coatings from the teeth, the function of oral and dental hygiene preparations is to prevent tooth disease, such as caries.
One known strategy is to protect the enamel against, or make it more resistant to, attack. For example, it is known that a thin protein film (the so-called pellicle) on the teeth formed from the constituents of the saliva protects the teeth against excessive mineral losses. It is also known that this protein film consists of phosphoproteins which bear phosphoric acid groups attached to serine and which adhere particularly firmly to the enamel surface. In addition, it is known (W082/03008) that phosphoproteins can be added to dental care preparations to reduce the dissolution of hydroxyapatite, the main constituent of dental enamel.
It has also long been standard practice to add fluorine in the form of water-soluble fluorides or monofluorophosphates to oral and dental hygiene preparations in order to increase the resistance of the enamel to attack by caries.
DESCRIPTION OF THE INVENTION
Summary of the Invention
It has now surprisingly been found that the enamelprotecting and demineralization-inhibiting effect of fluorine can be considerably improved by even small additions of phosvitin. This is totally unexpected because far weaker effects are obtained with phosphoproteins alone than with fluoride.
Accordingly, the present invention relates to oral and dental hygiene preparations in the form of aqueous, aqueous-alcoholic or water-free compositions which, for protection against demineralization of the enamel, contain a combination of fluoride or monofluorophosphate and phosvitin or water-soluble salts thereof in such a quantity that, when used in the oral cavity, a concentration of at least 0.01% by weight of dissolved fluorine and at least 0.01% by weight of phosvitin is present.
Oral and dental hygiene preparations in the context of the invention are tooth powders, toothpastes, tooth gels, tooth creams, mouthwashes, oral rinses, lozenges and chewing gum.
DESCRIPTION OF PREFERRED EMBODIMENTS
In order to guarantee the minimum concentration of dissolved fluorine and phosvitin according to the invention in the oral cavity, preparations used in undiluted form, for example toothpastes, tooth gels, tooth creams, toothpowders and mouthwashes, must contain 0.01% to 0.2% by weight fluorine in the form of a water-soluble fluoride or monofluorophosphate and 0.01 to 0.4% by weight of phosvitin. This takes into account dilution by the saliva and the water used in the cleaning of teeth.
Mouthwash concentrates should contain a higher concentration of dissolved fluorine and phosvitin corresponding to the intended dilution ratio. Oral and dental hygiene preparations in the form of lozenges or chewing gum, of which the active ingredients are diluted several times with saliva in use, should contain approximately 0.05 to 1% by weight of fluorine in the form of water-soluble fluoride or monofluorophosphate and 0.1 to 2% by weight of phosvitin.
Alkali metal fluorides, for example sodium fluoride, magnesium fluoride, zinc fluoride and tin fluoride, and also fluorides of amino compounds and surface-active quaternary ammonium fluorides may be present as the water-soluble fluorine compounds. Alkali metal monofluorophosphates for example sodium monofluorophosphate, may also be used.
Phosvitin is a glycophosphoprotein which is isolated by known methods from the yolk of birds' and amphibians' eggs and from fish roes. There are various types of phosvitins, a principal phosvitin component having a molecular weight of 34,000 to 36,000 daltons and a smaller
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A Sensitive Pyramidal Diamond Tool, Knoop et al., pp. 39-61, (1939).
D. B. Boyer et al., Remineralozation orf dentin in vitro, Chem. Abstract, (1976).
Laska Hans
Ploeger Walter
Wuelknitz Peter
Henkel Kommanditgesellschaft auf Aktien
Jaeschke Wayne C.
Rose Shep K.
Szoke Ernest G.
Wisdom, Jr. Norvell E.
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