Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1996-10-31
1998-01-27
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424435, A61K 716, A61K 914, A61K 990, A61K 31725
Patent
active
057119384
DESCRIPTION:
BRIEF SUMMARY
The present invention relates to oral hygiene compositions containing in combination certain polysaccharide components, a process to improve oral hygiene in mammals including man and the use of combinations of polysaccharides for the manufacture of dentally active oral hygiene compositions.
Even if the present invention relates in general to oral hygiene it will primarily be illustrated in connection with periodontitis, i.e. so called teeth loosening, and measures aiming at reducing active plaque, i.e. bacterial deposits on the surface of the tooth.
Periodontitis is a collagen disease resulting in decomposition of the supporting tissue of the tooth, periodontal ligaments and bone tissue. This results in weakening of the attachment apparatus, finally resulting in loosening of the tooth. The tooth loosening procedure is inflammatoric and the cause is found in the bacterial plaques accumulated on the surface of the tooth and against which the immune defense of the body is not capable of adequate defense. P The symptoms in periodontitis is generally in an early stage an inflammatoric change of the gingiva, i.e. the gums, which swells, reddens and becomes lightly bleeding on probing. In the transit from gingivitis to periodontitis, the latter constituting the destructive part of the cause of the disease, the collagenous threads surrounding the attachment, the periodontium, are destroyed, and simultaneously plaques spread down into the periodontal pocket developed during the course of the disease. This results in deepening and inflammation of the pocket, and as the pathological periodontal pocket deepens the tooth loses more and more of its attachment thereby obtaining increased mobility.
The traditional treatment of the disease conditions mainly aim towards active plaques, i.e. bacterial deposits on the surface of the tooth. The self-care of the patient in the form of thorough oral hygiene is of decisive importance in this connection. Usually the mechanical oral hygiene, tooth brushing, and interstitial hygiene using thread or stick, is the most common and effective procedure. However, there are different chemical possibilities of affecting or preventing bacerial growth or bacterial adherence to the tooth.
Professional tooth cleaning using a tooth hygienist and/or a dentist who removes plaque present and cleans the deep periodontal pockets inaccessible through common tooth cleaning reduces or eliminates the inflammation. If such cleaning of the tooth does not give the desired effect when carried out through the opening of the periodontal pocket a surgical treatment must be carried out. The gums are then folded aside so as to give full access to the pocket thereby enabling thorough cleaning.
By means of different membranes the tissues can be kept apart during the course of healing and the tissue which is desired in healing will have precedence. This techniques are named "Guided Tissue Regeneration", abbreviated GTR. GTR-treatment is presently the only way of providing periodontal healing with renewed growth of periodontal supporting tissue. Since the healing process is controlled by a barrier giving priority to the slow periodontal ligament tissue, it is also conceivable to affect the process by means of substances that can affect the regenerative rate thereof.
Oral compositions for the treatment of inter alia caries, periodontoclasia and foul breath are known. For example, GB,A, 2132889 discloses such oral compositions containing chitosan. Furthermore, oral compositions to inhibit or prevent periodontoclasia and caries containing certain sulphated polysaccharides are previously known from WO,A1, 8404453.
It is also previously known to combat plaque using certain negatively charged polysaccharides, such as from EP,A1, 0 324 720 and GB,A, 2215730.
Pharmaceutical compositions, inter alia in the form of a gel, for example for non-topical wound treatment containing one, two or several glycose aminoglykans, such as heparin, condroitin sulphate and chitosan, are previously known from WO,A1, 9312801. Furthermore, hypog
REFERENCES:
patent: 4512968 (1985-04-01), Komiyama et al.
patent: 4767463 (1988-08-01), Brode et al.
patent: 4879281 (1989-11-01), Shibasaki et al.
patent: 4925677 (1990-05-01), Feijen
patent: 4933182 (1990-06-01), Higashi et al.
patent: 5036056 (1991-07-01), Kludas
patent: 5041292 (1991-08-01), Feijen
patent: 5049403 (1991-09-01), Larm et al.
patent: 5055298 (1991-10-01), Kludas
patent: 5182103 (1993-01-01), Nakane et al.
patent: 5192362 (1993-03-01), Harvey et al.
patent: 5213898 (1993-05-01), Larm et al.
patent: 5290559 (1994-03-01), Groves
patent: 5554388 (1996-09-01), Illum
patent: 5645844 (1997-07-01), Henderson et al.
Solovyeva et al Chem. Abstr. 121(3) #26652 18 Jul., 1994.
Derwent Abstract of Endo JP 59112922 (Jun. 29, 1984).
Medicarb AB
Rose Shep K.
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