Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1993-03-30
1995-08-01
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 31195
Patent
active
054380758
ABSTRACT:
Glutamine is administered orally at a rate of about 4.5 g/m.sup.2 per day to treat oropharyngeal mucositis. This is administered to patients that experience or may develop oropharyngeal mucositis, especially those caused by chemotherapy or radiotherapy.
REFERENCES:
patent: 5039704 (1991-08-01), Smith et al.
"A Review of the Effects of Glutamine Enriched Diets on Experimentally Induced Enterocolitis", vol. 14, No. 4, Supplement in Journal of Parenteral and Enteral Nutrition. (1990).
"Oral Glutamine Reduces Bacterial Translocation following Abdominal Radiation" by Wiley Souba et al in Journal of Surgical Research 48, 1-5 (1990).
"Effect of a Glutamine Supplemented Enteral Diet on Methotrexate-Induced Enterocolitis" by Andrew D. Fox in Journal of Parenteral and Enteral Nutrition, 12(4):325-331 (1988).
"Dietary Manipulation of Methotrexate-Induced Enterocolitis" by Jin Shou et al in Journal of Parenteral and Enteral Nutrition vol. 15, No. 3, p. 307, (1991).
"Does Glutamine Contribute to Immunosuppression after major burns" by Mark Parry-Billings et al in The Lancet, vol. 336:523-525 (1990).
"Glutamine Nutrition and Requirements" by Robert J. Smith et al in Journal of Parenteral and Enteral Nutrition vol. 14, No. 4 Supplement, Jul./Aug. 1990.
"New Fuels For the Gut" by Sarah T. O'Dwyer in Chemical Tube Feeding, 1990.
"Clinical and Metabolic Efficacy of Glutamine Supplemented Parenteral Nutrition after Bone Marrow Transplantation" by Thomas Ziegler et al in Ann. Int. Med. 116:821-828, (1992).
"Combined Effects of Glutamine and Epidermal Growth Factor on the Rat Intestine" by Danny O. Jacobs, et al in Surgery, p. 558. vol. 104, No. 2 (Aug., 1988).
"Total Parenteral Nutrition, Glutamine and Tumor Growth" by Josef E. Fischer in J. Parenter. Enteral. Nutr. 14:86S-89S, (1990).
Abstract: Effect of Route of Glutamine Administration GM Mortality Following Experimental Enterocolitis, by D. J. Burke, 14th Clinical Congress Abstract col. 14, No. 1, Supplement. (1990).
"Reduction of The severity of Enterocolitis by Glutamine-Supplemented Enteral Diets" by Andrew D. Fox et al, in Surgical Form, 1987, 38:43-44.
"Total Parenteral Nutrition and Bowel Rest Modify and Metabolic Response to Endotoxin in Humans" by Yuman Fong et al in Ann. Surg, Oct. 1989, vol. 210, No. 4.
"Glutamine Enhanced Enteral Diet Improves Nitrogen Balance Without Increasing Portal Ammonia", M. G. Brown, et al in Br. J. Surg. 1991, vol. 78, Nov. 1305-1306.
"Disparate Effects of 5-fluorouracil on the Ileum and Colon of Enterally Fed Rats with Protection by Dietary Glutamine" in Surgical Forum, p. 45. (1988).
"Ten Versus TPN Following Major Abdominal Trauma-Reduced Septic Morbidity" by Frederick A. Moore, in The Journal of Trauma, vol. 29, No. 7. (1989).
"Absorption and Metabolic Effects of Enterally Administered Glutamine in Humans", by Pierre Dechelotte, in American Physiological Society, 1991, p. G677.
"Glutamine Nutrition in the Management of Radiation Enteritis" by Wiley Souba et al in Journal of Parenteral and Enteral Nutrition, vol. 14, No. 4, Supplement, p. 106S-107S (1990).
"Adjuvant parenteral nutrition in the patient with cancer", by Josef E. Fischer M.D., in Surgery 96:, vol. 96, No. 3, pp. 578-580. (1984).
"Effects of Nutrition on Tumor Growth and Tolerance to Chemotherapy" by Ezra Steiger et al in J. Surg. Res. 18:455-461, 1975.
"Parenteral Nutrition in Patients Receiving Cancer Chemotherapy" by American College of Physicians, a position paper in 1989 American College of Physicians, p. 734.
Abstract: Parenteral Nutrition Results in Bacterial Translocation from the Gut & Death Following Chemotherapy; J. C. Alverdy, M.D. et al from 14th Clinical Congress Abstract vol. 14, No. 1. Supplement (1990).
"Glutamine Utilization by the Small Intestine" by Herbert G. Windmueller; Adv. Enzymology 53:202-231, 1982.
"Parenteral Nutrition in Patients Receiving Cancer Chemotherapy" in 1989 Ann. Intern. Med., 110:734-736.
"Effects of Oral Supplementation of Glutamine On Small Intestinal Musosal Mass Following Resection" by John A. Vanderhoof et al in Journal of the American College of Nutrition. vol. 11:223-227 (1992).
Abstract: "5-Fluorouracil Toxicity on Small Intestinal Mucosa But Not White Blood Cells in Decreased by Glutamine", ST. O'Dwyer, T. Scott et al in Clinical Research, vol. 35 No. 3, 1987.
"The Effect of Dietary Glutamine and Dietary RNA on Ileal Flora, Ileal Histology, and Bacterial Translocation in Mice" by Carol L. Wells et al in Nutrition vol. 6, No. 1, 1990.
"The Gut as a Nitrogen-Processing Organ in the Metabolic Response to Critical Illness" by Wiley W. Souba, M.D., in Nutritional Support Services, vol. 8, No. 5, pp. 15-22, May 1988.
"Intestinal fuels: Glutamine, short-chain fatty acids, and dietary fiber" by Mary Ann Evans et al in Journal of the American Dietetic Association, Oct. 1992, vol. 92, No. 10, p. 1239.
"Intestinal Consumption of Intravenously Administered Fuels" by Wiley W. Souba et al in Journal of Parenteral and Enteral Nutrition., 1985, vol. 9, No. 1.
"Glutamine Nutrition Theoretical Considerations and Therapeutic Impact" by Wiley W. Souba et al in Journal of Parenteral and Enteral Nutrition., 1990, vol. 14, No. 5, Supplement.
"Effects of Glutamine-Supplemented Diets on Immunology of the Gut" by John G. Alverdy, Journal of Parenteral and Enteral Nutrition 1990 vol. 14, No. 4 Supplement.
"Oral Glutamine Accelerates Healing of the Small Intestine and Improves Outcome After Whole Abdominal Radiation" by V. Suzanne Klimberg et al in Arch Surg, vol. 125:1040-1045 (1990).
"Glutamine-Supplemented Toal Parenteral Nutrition Improves Gut Immune Function" by David J. Burke, in Archsurg, vol. 124, Dec. 1989., p. 1396.
"Intestinal Metabolism of Glutamine and Glutamate from the Lumen As Compared to Glutamine From Blood" by Herbert G. Windmueller, In Archives of Biochemistry and Biophysics, 171, 662-672 (1975).
"Respiratory Fuels and Nitrogen Metabolism in Vivo in Small Intestine and Fed Rats" by Herbert G. Windmueller et al in Journal of Biological Chemistry, vol. 255, No. 1, Jan. 1980, pp. 107-112.
"Prophylactic Glutamine Protects the Intestinal Mucosa From Radiation Injury" by V. Suzanne Klimberg, in Cancer, July 1990, vol. 66, p. 62.
"Safety and Metabolic Effects of L-Glutamine Administration of Humans" by Thomas Ziegler et al in Journal of Parenteral and Enteral Nutrition. 14:137s-146s, 1990.
"Splanchnic Exchange of Amino Acids after Amino Acid Ingestion in Patients with Chronic Renal Insufficiency.sup.1-4"., by Giacomo Deferrari et al in Am. J. Clin. Nutr. 48:72-83, 1988.
Anderson Peter M.
Skubitz Keith M.
LandOfFree
Oral glutamine to reduce stomatitis does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oral glutamine to reduce stomatitis, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral glutamine to reduce stomatitis will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-734029