Oral formulations of glycyl-2-methylprolyl-glutamate

Details Oral formulations of glycyl-2-methylprolyl-glutamate Oral formulations of glycyl-2-methylprolyl-glutamate

2011-02-15

2011-02-15

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

C424S464000, C424S451000, C548S537000, C514S423000

Reexamination Certificate

active

07887839

ABSTRACT:
Oral formulations of G-2MePE including microemulsions, coarse emulsions, liquid crystals, tablets and encapsulated forms of G-2MePE have improved bioavailability than conventional aqueous formulations. In particular, microparticles, nanoparticles and microemulsions can exhibit great neuroprotective effects after oral administration. In a microemulsion formulation, G-2MePE can nearly completely inhibit cerebral infarction in an animal model of stroke even after the stroke had been initiated. Thus, improved oral formulations can be desirably used to treat a variety of neurodegenerative conditions with improved convenience and improved efficacy.

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Bickerdike, Michael J.; NNZ-2566: a gly-pro-glu analogue with neuroprotective efficacy in a rat model of acute focal stroke; Journal of the Neurological Sciences 278 2008: 85-90; Elsevier B.V.

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