Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1994-03-02
1998-08-11
Sayala, Chhaya D.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 852, 4241411, 4241841, 424465, 424474, 424489, 424491, 424499, 514 2, 514 12, 514 21, 514773, A61K 3821
Patent
active
057924511
ABSTRACT:
The present invention relates to an oral drug delivery system, and in particular to modified amino acid derivatives for use as a delivery system of sensitive agents such as bioactive peptides. The modified amino acid derivatives can form non-covalent mixtures with active biological agents and in an alternate embodiment can releasably carry active agents. These mixtures are suitable for oral administration of biologically active agents to mammals. Methods for the preparation of such amino acids are also disclosed.
REFERENCES:
patent: Re24899 (1960-11-01), Green
patent: 2671451 (1954-03-01), Bolger
patent: 2862918 (1958-12-01), Meyer et al.
patent: 2868740 (1959-01-01), Luce
patent: 2971916 (1961-02-01), Schleicher et al.
patent: 3016308 (1962-01-01), Macaulay
patent: 3052655 (1962-09-01), Fox et al.
patent: 3057344 (1962-10-01), Abella et al.
patent: 3076790 (1963-02-01), Fox et al.
patent: 3170802 (1965-02-01), Fukushima
patent: 3190837 (1965-06-01), Brynko et al.
patent: 3474777 (1969-10-01), Figge et al.
patent: 3491093 (1970-01-01), Pachter et al.
patent: 3565559 (1971-02-01), Sato
patent: 3567650 (1971-03-01), Bakan
patent: 3574832 (1971-04-01), Engel et al.
patent: 3576758 (1971-04-01), Emrick
patent: 3687926 (1972-08-01), Arima et al.
patent: 3725113 (1973-04-01), Chang
patent: 3748277 (1973-07-01), Wagner
patent: 3794561 (1974-02-01), Matsukawa et al.
patent: 3795739 (1974-03-01), Birkmayer et al.
patent: 3816404 (1974-06-01), Kablaoui et al.
patent: 3822348 (1974-07-01), Higashi et al.
patent: 3849550 (1974-11-01), Teitelbaum
patent: 3933873 (1976-01-01), Love et al.
patent: 3937668 (1976-02-01), Zolle
patent: 3939253 (1976-02-01), Bodor et al.
patent: 3956172 (1976-05-01), Saeki et al.
patent: 3962416 (1976-06-01), Katzen
patent: 3976773 (1976-08-01), Curran
patent: 4035507 (1977-07-01), Bodor et al.
patent: 4048268 (1977-09-01), Ludwig
patent: 4061466 (1977-12-01), Sjoholm et al.
patent: 4117801 (1978-10-01), Dannelly et al.
patent: 4147767 (1979-04-01), Yapel
patent: 4183849 (1980-01-01), Hansen
patent: 4199561 (1980-04-01), Roth et al.
patent: 4217370 (1980-08-01), Rawlings et al.
patent: 4239635 (1980-12-01), Rieder
patent: 4272506 (1981-06-01), Schwarzberg
patent: 4289759 (1981-09-01), Heavner et al.
patent: 4345588 (1982-08-01), Widder et al.
patent: 4348384 (1982-09-01), Horikoshi et al.
patent: 4351337 (1982-09-01), Sidman
patent: 4352883 (1982-10-01), Lim
patent: 4357259 (1982-11-01), Senyei et al.
patent: 4388304 (1983-06-01), Nyeki et al.
patent: 4393192 (1983-07-01), Curatolo et al.
patent: 4402856 (1983-09-01), Schnoring et al.
patent: 4405598 (1983-09-01), Brown
patent: 4442090 (1984-04-01), Kakeya et al.
patent: 4446138 (1984-05-01), Pack
patent: 4450150 (1984-05-01), Sidman
patent: 4460563 (1984-07-01), Calanchi
patent: 4462839 (1984-07-01), McGinley et al.
patent: 4462991 (1984-07-01), Higuchi et al.
patent: 4473620 (1984-09-01), Wu et al.
patent: 4483807 (1984-11-01), Asano
patent: 4492684 (1985-01-01), Goosen et al.
patent: 4518433 (1985-05-01), McGinley et al.
patent: 4590265 (1986-05-01), Bogan et al.
patent: 4608278 (1986-08-01), Frank
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4647455 (1987-03-01), De Bold
patent: 4666641 (1987-05-01), Fickat et al.
patent: 4671954 (1987-06-01), Goldberg
patent: 4673566 (1987-06-01), Goosen et al.
patent: 4690786 (1987-09-01), Ninomiya et al.
patent: 4692284 (1987-09-01), Braden
patent: 4703042 (1987-10-01), Bodor
patent: 4708952 (1987-11-01), Salatinjants
patent: 4745161 (1988-05-01), Saudek et al.
patent: 4753804 (1988-06-01), Iaccheri et al.
patent: 4757007 (1988-07-01), Satoh
patent: 4757024 (1988-07-01), Roper
patent: 4757066 (1988-07-01), Shiokari et al.
patent: 4766012 (1988-08-01), Valenti
patent: 4774320 (1988-09-01), Tagliabue et al.
patent: 4789734 (1988-12-01), Pierschbacher
patent: 4835312 (1989-05-01), Itoh et al.
patent: 4837381 (1989-06-01), Steber et al.
patent: 4844904 (1989-07-01), Hamaguchi et al.
patent: 4873087 (1989-10-01), Morishita et al.
patent: 4886663 (1989-12-01), Houghten
patent: 4895725 (1990-01-01), Kantor et al.
patent: 4897444 (1990-01-01), Brynes et al.
patent: 4900730 (1990-02-01), Miyauchi
patent: 4908233 (1990-03-01), Takizawa et al.
patent: 4919939 (1990-04-01), Baker
patent: 4925673 (1990-05-01), Stein
patent: 4963364 (1990-10-01), Fox et al.
patent: 4976968 (1990-12-01), Steiner
patent: 4983402 (1991-01-01), Steiner
patent: 4996292 (1991-02-01), Fox et al.
patent: 5019400 (1991-05-01), Gombotz et al.
patent: 5023374 (1991-06-01), Simon
patent: 5039481 (1991-08-01), Pacifici et al.
patent: 5041291 (1991-08-01), Bader et al.
patent: 5055300 (1991-10-01), Gupta
patent: 5066487 (1991-11-01), Morelle et al.
patent: 5067961 (1991-11-01), Kelman et al.
patent: 5069936 (1991-12-01), Yen
patent: 5077278 (1991-12-01), Hafner et al.
patent: 5100669 (1992-03-01), Hyon et al.
patent: 5100918 (1992-03-01), Sunshine et al.
patent: 5122367 (1992-06-01), Ron et al.
patent: 5126147 (1992-06-01), Silvestri et al.
patent: 5137892 (1992-08-01), Chu et al.
patent: 5186947 (1993-02-01), Goettsche et al.
patent: 5204099 (1993-04-01), Barbier et al.
patent: 5206384 (1993-04-01), Shibahara et al.
patent: 5216124 (1993-06-01), Hansen, Jr. et al.
patent: 5244653 (1993-09-01), Berke et al.
patent: 5250236 (1993-10-01), Gasco
patent: 5271934 (1993-12-01), Goldberg et al.
patent: 5271961 (1993-12-01), Mathiowitz et al.
patent: 5278148 (1994-01-01), Baranca et al.
patent: 5310535 (1994-05-01), Kruper, Jr. et al.
patent: 5328992 (1994-07-01), Peter et al.
patent: 5352461 (1994-10-01), Feldstein et al
patent: 5384133 (1995-01-01), Boyes et al.
patent: 5389377 (1995-02-01), Chagnon et al.
patent: 5389379 (1995-02-01), Dirix et al.
patent: 5401516 (1995-03-01), Milstein et al.
patent: 5418010 (1995-05-01), Janda et al.
patent: 5443841 (1995-08-01), Milstein et al.
patent: 5447728 (1995-09-01), Milstein et al.
patent: 5451410 (1995-09-01), Milstein et al.
patent: 5536813 (1996-07-01), Charpenel et al.
patent: 5540939 (1996-07-01), Milstein et al.
patent: 5578323 (1996-11-01), Milstein et al.
patent: 5601846 (1997-02-01), Milstein et al.
Kondo, Microcapsule Processing and Technology, pp. 154-165, 1979.
Pastores et al., Journal of Liquid Chromatography, 18:3049-3059, 1995.
Sinha et al., Journal of Biological Chemistry, 260:10714-10719, 1985.
Franssen et al., J. Med. Chem., 35:1246-1259, 1992.
Chemical Abstracts, 99(23):191473h, Dec. 5, 1983.
Butera et al., J. Med. Chem., 34:3212-3228, 1990.
Cimini et al., Ann. Rept. in Med. Chem., 27:89-98, 1992.
Earley et al., Brain Research, 546:282-286, 1991.
Ellingboe et al., J. Med. Chem., 35:705-716, 1992.
Lumma et al., J. Med. Chem., 30:758-763, 1987.
Lynch et al., J. Pharm. and Exp. Therap., 269:541-554, 1994.
Matsuno et al., Brain Research, 575:315-319, 1992.
Morgan et al., J. Med. Chem., 33:1091-1097, 1990.
Oinuma et al., J. Med. Chem., 33:903-905, 1990.
Rao et al., Molecular Pharmacology, 37:978-982, 1990.
Thompson, Biochem, vol. 12(1), pp. 47-51, 1973.
Thompson et al., J. Med Chem., vol. 29(1), 1986 pp. 104-111 (abstract only).
Douglas et al., Chemistry and Industry, 22:748-751, 1985.
Finch, Chemistry and Industry, 22:752-756, 1985.
Marie-Claude Fournie-Zulaski et al., "New Carboxyalkyl Inhibitors of Brain Enkephalinase: Synthesis, Biological Activity, and Analgesic Properties", J. Med. Chem., 26, 60-65 (1983).
Roulhwai Chen et al., "Evidence for Hemiacetal Formation between N-Acyl-L-phenylalaninals and .alpha.-Chymotrypsin by Cross-Saturation Nuclear Magnetic Resonance Spectroscopy", vol. 18, No. 5, pp. 921-925 (1979).
Kenneth R. Davis et al., "Leucinal Inhibits Brain Aminopeptidase Activity and Potentiates Analgesia Induced by Leu-Enkephalin", Pharmacology Biochemistry & Behavior, vol. 19, pp. 791-794 (1983).
Charles V. Jackson et al., "Pharmacological Assessment of the Antithrombotic Activity of the Peptide Thrombin Inhibitor, D-Methyl-Phenylalanyl-Prolyl-Arginal (GYK1-14766), in a Canine Model of Coronary Artery Thrombosis", The Journal of Pharmacology And Experimental Therapeutics, vol. 261, No. 1, pp. 546-552 (1992).
Airaudo, C.B. et al. (1987) Jour
Leone-Bay Andrea
Paton Duncan R.
Sarubbi Donald J.
Emisphere Technologies Inc.
Sayala Chhaya D.
LandOfFree
Oral drug delivery compositions and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oral drug delivery compositions and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral drug delivery compositions and methods will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-386406