Oral dosage form of biologically active proteins

Details Oral dosage form of biologically active proteins Oral dosage form of biologically active proteins

1993-12-15

1997-01-28

Wax, Robert A.

Drug, bio-affecting and body treating compositions

Lymphokine

424456, 424457, 424460, 424491, 424499, 514 2, 514 8, 514 12, 514 21, A61K 4505, A61K 964, A61K 3819, A61K 3822

Patent

active

055975623

ABSTRACT:
An oral dosage form comprising: (a) granulocyte colony stimulating factor or erythropoietin; (b) surfactant(s); (c) fatty acid(s); and (d) enteric material. The oral drug preparations provided by the present invention avoid inactivation of the principal ingredient during the process of pharmaceutical manufacturing and display enhanced absorption of the ingredient from the intestinal tract, particularly as a result of the addition of fatty acid(s) to the drug composition. As such, oral dosage forms of the present invention can allow for dosage reductions, facilitate accurate dose control, and increase the practical usefulness of the bioactive proteins.

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