Oral dosage form comprising a therapeutic agent and an...

Details Oral dosage form comprising a therapeutic agent and an... Oral dosage form comprising a therapeutic agent and an...

2008-06-10

2008-06-10

Tran, S. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S451000, C424S457000, C424S458000, C424S464000, C424S468000, C424S469000, C424S472000, C424S484000, C424S490000

Reexamination Certificate

active

07384653

ABSTRACT:
The present invention provides an oral dosage form comprising a first composition and a second composition. The first composition comprises an effective amount of a therapeutic agent and the second composition comprises an effective amount of an adverse-effect agent. The adverse-effect agent is covered with a coating that is substantially insoluble in the gastrointestinal tract. In one embodiment, the adverse-effect agent is coated with an outer base-soluble layer and an inner acid-soluble layer. The therapeutic agent can be uncoated or can be coated with a coating having an outer acid-soluble layer and an inner base-soluble layer. The dosage form discourages administration of the therapeutic agent by other than oral administration.

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