Oral dosage composition comprising zonnula occludens toxin and a

Details Oral dosage composition comprising zonnula occludens toxin and a Oral dosage composition comprising zonnula occludens toxin and a

1995-05-24

1998-10-27

Bawa, Raj

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424464, 4242361, 4241301, 4241841, 424800, 424804, 424806, 514 2, 514 3, 514837, 514866, A61K 928, A61K 948

Patent

active

058275347

ABSTRACT:
An oral dosage composition for intestinal delivery of a therapeutic agent comprising:

REFERENCES:
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Fasano et al, Mechanism of Action of Zonula Occludens Toxin (ZOT) Elaborated by Vibrio Cholerae, 29th Joint Conference on Cholera and Related Diarrheal Diseases, p. 214 (1993).
Chapron et al, "Gastric Retention of Enteric-Coated Magnesium Chloride Tablets" Abstract, Annals of Pharmacology, 28(7-8):874-877 (1994).
Digenis et al, "Cross-Linking of Gelatin Capsules and Its Relevance to Their In Vitro-In Vivo Performance", Abstract, J. of Pharmaceutical Sciences, 83(7):915-921 (1994).
Vantini et al, In Vitro Study of a New Pancreatic Enzyme with High Lipase Content in Enteric Coated Microtablets, Abstract, Clinica Terapeutica, 142(5):445-451 (1993).
Yoshitomi et al, "Evaluation of Enteric Coated Tablet Sensitive to Pancreatic Lipase", Abstract, Chemical and Pharmaceutical Bulletin, 40(7):1902-1905 (1992).
Thoma et al, "The Solubility Kinetics of Enteric-Resistant Tablets Using Riboflavin Test Tablets. 6. Pharmaceutic-Technologic and Analytic Studies on Gastric Juice-Resistant Dosage Forms", Abstract, Pharmazie, 46(5):331-336 (1991).
Morishita et al, "Controlled Release Microspheres Based on Eudragit L100 for the Oral Administration of Erythromycin", Abstract, Drug Design and Delivery, 7(4):309-319 (1991).
Lin et al, "Tablet Formulation Study of Spray-dried Sodium Diclofenac Enteric-Coated Microcapsules", Abstract, Pharmaceutical Research, 8(7):919-924 (1991).
Hardy et al, "Evaluation of an Enteric and Therapeutics", Abstract, Alimentary Pharmacology and Therapeutics, 5(1):69-75 (1991).
Fasano et al, Mechanism of Action of Zonula Occludens (ZOT) Elaborated by Vibrio Cholerae, Abstract (B-13), p. 31, 94th ASM General Meeting (May 23-27, 1994).
Guandalini et al, "Acute Infectious Diarrhoea", Management of Digestive and Liver Disorders In Infants and Children, pp. 319-349 (1993).
Fasano et al, Vibrio Cholerae Produces a Second Enterotoxin, Which Affects Intestinal Tight Junctions, Proc. Natl. Acad. Sci. USA, 88:5242-5246 (1991).
Baudry et al, "Cloning of a Gene (zot) Encoding a New Toxin Produced by Vibrio Cholerae", Infection and Immunity, 60(2):428-434 (1992).
Leong et al "Identification of the Integrin-Binding Domain of the Yersinia Pseudotuberculosis Invasin Protein", The EMBO Journal, 9(6):1979-1989 (1990).
Fasano et al, Regulation of Intestinal Tight Junctions By Zonula Occludens Toxin (ZOT) Elaborated by Vibrio Cholerae, Abstract, Clinical Research, 42(2):286A (1994).
Fasano et al, Mechanism of Action of Zonula Occludens Toxin (ZOT) Elaborated by Vibrio Cholerae, Abstract (1060), Pediatric Research, 35(4/2):179A (1994).
Fasano et al, Mechanism of Action of Zonula Occludens Toxin (ZOT) Elaborated by Vibrio Cholerae, Abstract, Gastroenterology, 106(4):A232 (1994).
Kasper et al, "Cholera", Clinical Microbiology Reviews, 8(1):48-86 (1995).
Levine, "Current Status of Vaccine Development for Enteric Diseases", Seminars in Pediatric Infectious Diseases, 5(3):243-250 (1994).

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