Oral diclofenac preparation

Details Oral diclofenac preparation Oral diclofenac preparation

1994-04-21

1998-01-27

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424461, 424494, 424497, A61K 916, A61K 958, A61K 962

Patent

active

057119678

ABSTRACT:
The novel diclofenac preparation with controlled release is in the form of pellets. The active ingredient, applied to inert pellets, is coated with a membrane layer which contains, in addition to 35-65% by weight of a water-insoluble polymer, 5-20% by weight of at least one water-soluble and/or water-insoluble pore-forming agent and 20-50% by weight of adjuncts. The pore-forming agents permit a very uniform release of diclofenac such that administration twice a day is sufficient. A film coating resistant to gastric juice is applied over the membrane layer.

REFERENCES:
patent: 4871549 (1989-10-01), Ueda et al.
patent: 4900557 (1990-02-01), Dell et al.
patent: 4954350 (1990-09-01), Jones et al.
patent: 4968505 (1990-11-01), Okada et al.
patent: 4980170 (1990-12-01), Schneider et al.
patent: 5026560 (1991-06-01), Makino et al.
patent: 5068112 (1991-11-01), Samejima et al.
patent: 5096717 (1992-03-01), Wirth et al.
patent: 5102668 (1992-04-01), Eichel et al.

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