Oral cyclosporin formulations

Details Oral cyclosporin formulations Oral cyclosporin formulations

1997-10-23

1999-10-05

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, A61K 950, A61K 910, A61K 4734

Patent

active

059620196

ABSTRACT:
Improved oral cyclosporin formulations which have high bioavailability and are capable of administration in both liquid and hard capsule form are provided. In the subject formulations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol solvent of from 2 to 3 carbon atoms in combination with at least one non-ionic surfactant. The subject formulations may further comprise at least one cosolvent, where cosolvents of interest include fatty acids and diols. The subject formulations find use in immuno-suppressive therapy.

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