Oral compositions of proteinaceous medicaments

Details Oral compositions of proteinaceous medicaments Oral compositions of proteinaceous medicaments

1991-11-25

1993-04-27

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424455, 424463, 424474, 424490, A61K 910, A61K 948, A61K 966, A61K 3702

Patent

active

052062198

ABSTRACT:
Proteinaceous medicaments such as erythropoetin, insulin and calcitonin are formulated in a medium comprising a polyol pharmaceutical solvent combined as co-solvent with a lipid pharmaceutical solvent. The formulation is adapted for oral administration as a liquid as well as a filled hard or soft gelatin capsule. The preferred polyol solvent is polyethylene glycol/propylene glycol; the preferred lipid solvent is oleic acid.

REFERENCES:
patent: 4356167 (1982-10-01), Kelly
patent: 4579730 (1986-04-01), Kidron
patent: 4849227 (1989-07-01), Cho, III
patent: 4880835 (1989-11-01), Park
patent: 4910021 (1990-03-01), Davis et al.
Ritschel Meth Find Exp Clin. Pharmacol. 13(3): 205-220 (1991).
Shichiri et al. Acta Diabet. Lat. 15: 175-183 (1978).

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