Oral compositions for the treatment of non-diabetic obese...

Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Heavy metal or compound thereof

Reexamination Certificate

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C514S492000, C514S909000

Reexamination Certificate

active

07122209

ABSTRACT:
Oral compositions containing an effective amount of a tungsten compound (VI), preferably a tungstate salt, more preferably sodium tungstate (Na2WO4), are useful in controlling obesity/overweightness in non-diabetic mammals, including humans. The anti-obesity effect of sodium tungstate dihydrate in rats has been determined in a cafeteria-diet-induced obesity model. Said obese rats are good models of obese, non-diabetic mammals, including humans. The prophylactic, therapeutic and/or cosmetic treatment resulting from this invention is surprising. It provides advantages such as effectiveness, lack of toxicity and relatively low price in comparison with other treatments in prior art. Hence, the oral compositions according to the invention are useful for the treatment of obesity/overweightness in non-diabetic mammals, including humans.

REFERENCES:
patent: 5595763 (1997-01-01), Guinovart et al.
patent: 2 108 642 (1997-12-01), None
patent: 60 02 5 928 (1985-02-01), None
Cecil Textbook of Medicine, W.B. Saunders Co., Philadelphia, 1992, vol. 2, p. 1166.
J. Matsumoto, “Vanadate, Molybdate and Tungstate for Orthomolecular Medicine”. Medical Hypotheses, 1994, vol. 43, p. 177-182, p. 179, table 1.
J.D. Foster et al, “Tungstate: a Potent Inhibotor of multifunctional Glucose-6-Phasphatase”. Archiv. Biochem. Biophys., 1998, vol. 354, No. 1, p. 125-132.
International Search Report, 2002.

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