Drug – bio-affecting and body treating compositions – Dentifrices
Reexamination Certificate
2000-10-16
2002-04-30
Rose, Shep K. (Department: 1614)
Drug, bio-affecting and body treating compositions
Dentifrices
C424S058000
Reexamination Certificate
active
06379652
ABSTRACT:
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to an oral composition useful for reducing oral malodor.
2. The Prior Art
“Oral composition” means a composition for topical applications to the oral cavity to clean and care for the teeth as well as the oral cavity surfaces. Representative of such compositions are oral hygiene products for delivering therapeutic and cosmetic benefits to the oral cavity such as mouthwashes or rinses, toothpaste, dental gels, tooth powder, chewing gum, lozenges, strips and similar products. The benefits delivered by oral compositions include the suppression of dental calculus formation and the prevention of dental disorders such as caries, periodontitis and gingivitis as well as the elimination of halitosis.
Dental plaque is a deposit which forms on teeth and consists of inorganic and organic components derived from saliva, food and bacteria which are present in the oral cavity. When plaque undergoes calcification it forms dental calculus composed largely of calcium and orthophosphate arranged in a crystal lattice called hydroxyapatite.
Oral malodor, or halitosis, is caused by the putrefactive activity of microorganisms on appropriate substrate components of dental plaque, debris adhering to mucous membranes and salivary cellular elements to produce volatile sulfur compounds primarily hydrogen sulfide, methyl mercaptan and traces of methyl sulfide.
Methods of inhibiting volatile sulfur compounds to reduce the production of mouth odor have included the use of oral compositions such as toothpastes and mouthrinses containing antibacterial agents, such as, chlorhexidine. However, the side effects associated with chlorhexidine, such as a bitter taste and staining of the teeth, tongue, gums and oral mucosa, precludes the use of chlorhexidine in oral compositions.
Essential oils used as flavoring and taste masking agents in oral compositions are also known to the art to have antibacterial activity. Essential oils are aromatic compounds that are either derived from plant sources or are synthesized. Some essential oils show long lasting antiseptic effectiveness against the most common pathogens in the mouth most frequently associated with oral malodor, plaque, and gingivitis.
Essential oils have been used for years in antiseptic and antiplaque toothpastes. For example, U.S. Pat. No. 5,094,843 teaches an antiplaque toothpaste with a fluorine source, and a specific range of the essential oils thymol, menthol, methyl salicylate and eucalyptol.
U.S. Pat. No. 5,356,615 teaches an antiplaque oral composition, including a toothpaste containing the antibacterial agent Triclosan. The antiplaque activity of the Triclosan is increased by essential oils such as eucalyptol, thymol, methyl salicylate and menthol.
While the prior art discloses toothpaste and other oral compositions containing antiseptic essential oils, there is a continuing search by the art to improve and enhance the antiseptic efficacy of oral compositions prepared with these oils and particularly with the suppression of oral malodor.
SUMMARY OF THE INVENTION
In accordance with the present invention there is provided a method to suppress oral malodor to provide long lasting breath protection wherein there is applied to the oral cavity of the user an oral composition comprising an orally acceptable vehicle containing therein a flavor system comprised of a mixture of essential oils and a coolant compound, which is a menthol ester of naturally occurring hydrocarboxylic acids having 2 to 6 carbon atoms esterified with C
1
-C
4
alkyl groups.
DETAILED DESCRIPTION OF THE INVENTION
The term “coolant compound” as used herein means a compound which provides a cooling sensation when ingested or contacted with the body. These compounds are well known to the art. For example, German patent application 2608226 discloses compounds which exhibit a physiological cooling effect. The cooling compounds disclosed therein include menthol esters of naturally occurring hydroxycarboxylic acids having 2 to 6 carbon atoms which are esterified with C
1
-C
4
alkyl groups and include such menthyl esters such as menthyl acetate and menthyl lactate. It is these very same compounds when combined with essential oils having antibacterial properties have unexpectedly been discovered to substantially enhance the antibacterial efficacy of essential oil flavor systems and particularly with respect to the suppression of oral malodor.
A flavor system of the present invention which exhibits enhanced antibacterial activity concomitant with suppression of oral malodor is generally comprised of about 1 to about 50% by weight of the coolant compound preferably about 5.0 to about 30% by weight of the coolant compound and about 50 to about 99% by weight and more preferably 70 to about 95% by weight of one or more of antiseptic essential oil flavors such as thymol, eugenol, eucalyptus and tea tree oil, oil of wintergreen, oil of pepper mint, oil of spearmint, clove bud oil, menthol, anethole, methyl salicylate, cassia, sage, parsley oil, oxanone, alpha-irisone, marjoram, lemon, orange, propenyl guaethol, cinnamon, vanillin, ethyl vanillin, heliotropine, 4-cis-heptenal, diacetyl, methyl-para-tert-butyl phenyl acetate, and mixtures thereof.
The flavor system of the present invention is effective to impart odor suppression to oral care compositions when present in the oral care composition at concentrations of from about 0.5 to about 10.0 by weight and preferably at about 1 to about 2% by weight.
To further enhance the activity of the flavor system of the present invention, an antibacterial enhancing agent may be included in the oral composition. The use of such antibacterial enhancing agents in oral care compositions is known to the art, as for example, U.S. Pat. Nos. 5,188,821 and 5,192,531.
Antibacterial enhancing agents preferred for use in the practice of the present invention include a natural or synthetic anionic polycarboxylates having a molecular weight of about 1,000 to about 5,000,000, preferably about 30,000 to about 500,000. Synthetic anionic polycarboxylates are generally employed in the form of their free acids or preferably partially or more preferably fully neutralized water soluble alkali metal (e.g. potassium and preferably sodium) or ammonium salts. Preferred are 1:4 to 4:1 copolymers of maleic anhydride or acid with another polymerizable ethylenically unsaturated monomer, preferably methyl vinyl either/maleic anhydride having a molecular weight (M.W.) of about 30,000 to about 1,000,000, most preferably about 30,000 to about 500,000. These copolymers are available, for example, under the trade designation Gantrez AN 139 (M.W. 500,000), AN 119 (M.W. 250,000); and preferably Gantrez S-97 Pharmaceutical Grade (M.W. 70,000), of GAF Corporation.
Other anionic polycarboxylates useful in the practice of the present invention include the 1:1 copolymers of maleic anhydride with ethyl acrylate, hydroxyethyl methacrylate, N-vinyl-2-pyrollidone, or ethylene, the latter being available, for example, as Monsanto EMA No: 1103, M.W. 10,000 and Grade 61, and 1:1 copolymers of acrylic acid with methyl or hydroxyethyl methacrylate, methyl or ethyl acrylate, isobutyl methacrylate, isobutyl vinyl ether or N-vinyl-2-pyrrolidone.
Additional operative useful polycarboxylate compounds include copolymers of maleic anhydride with styrene, isobutylene or ethyl vinyl either, polyacrylic, polycationic and polymaleic acids, and sulfonacrylic oligomers of M.W. as low as 1,000 available under the trade designation Uniroyal ND-2.
Also useful in the practice of the present invention are the so-called carboxyvinyl polymers, commercially available, for example, under the trade designation Carbopol 934, 940 and 941 from B.F. Goodrich, these polymers consisting of a colloidally water-soluble polymer of polyacrylic acid crosslinked with from about 0.75% to about 2.0% of polyalkyl sucrose or polyalkyl pentaerythritol as a cross linking agent, often with M.W.'s up to 4-5 million or more.
The antibacterial enhancing agent, when empl
Hughes John
Liu Xiaoyan
Subramanyam Ravi
Williams Malcolm
Colgate - Palmolive Company
Rose Shep K.
Shapiro Paul
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