Oral compositions comprising hydroxamic acids and salts thereof

Details Oral compositions comprising hydroxamic acids and salts thereof Oral compositions comprising hydroxamic acids and salts thereof

1985-11-20

1987-04-28

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Dentifrices

Ammonia, amine, or derivative thereof

514575, 514835, A61K 3119, A61K 722

Patent

active

046613420

ABSTRACT:
There is provided an oral composition containing a hydroxamic acid represented by the formula R--CH.sub.2 --CO--NHOH (where R is an alkyl group or alkoxyphenyl group) or a salt thereof such as 2-(4-butoxyphenyl)acetohydroxamic acid, 2-(4-methoxyphenyl)acetohydroxamic acid, caprylohydroxamic acid, or laurohydroxamic acid. The oral composition prevents Streptococcus mutans from colonizing in the oral cavity and is effective in preventing dental caries and also in preventing and remedying periodontal disease.

REFERENCES:
patent: 3427381 (1969-02-01), Kirkland
patent: 3632764 (1972-01-01), Wakeman et al.
patent: 4022880 (1977-05-01), Vinson et al.
patent: 4093711 (1978-06-01), Blackburne et al.
patent: 4291045 (1981-09-01), Mackay et al.
Chem. Abst. 74:125092r, (1971)--Hase.
Chem. Abst. 77:92870z, (1972)--Noelser et al.
Chem. Abst. 87:63358q, (1977)--Wang et al.
Chem. Abst. 87:113115f, (1977)--Misato et al.

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