Oral compositions

Details Oral compositions Oral compositions

1991-01-08

1992-02-18

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

Fluorine or fluorine compound containing

424 49, 424 57, A61K 716, A61K 718

Patent

active

050892541

ABSTRACT:
The present invention relates to an anti-caries oral composition which comprises a fluorine-containing anti-caries agent and a particulate hydroxyapatite abrasive material. The compatibility of the hydroxyapatite with the fluorine compound is improved by pretreating the surface of the hydroxyapatite material with compounds that block the hydroxy groups, present at the surface of the hydroxyapatite. Such compounds are preferably alkaline materials such as sodium hydroxide, sodium-trimetaphosphate, tetrasodium pyrophosphate, sodium carbonate.

REFERENCES:
patent: 4193973 (1980-03-01), Jarvis et al.
patent: 4327079 (1982-04-01), Aoki
patent: 4342741 (1982-08-01), Aoki
patent: 4933173 (1990-06-01), Bristow et al.
patent: 4988499 (1991-01-01), Bristow et al.
Bristow et al C.A. 112:223165q (1988) of E.P. 346957 Dec. 20, 1989.
Bristow et al C.A. 112:204505j (1989) of E.P. 344832 Dec. 6, 1989.
Toyo Stauffer C.A. 112:164771j (1989) of JPN. 01164712 A2 Jun. 28, 1989.
Sakuma et al C.A. 111:83913j (1989) of GER. Off. DE 3821256 Jan. 5, 1989.
Causton C.A. 107:83939q (1986) of WO 8606274 Nov. 6, 1986.
Aoki C.A. 95:86157c (1979) of E.P. 29332 May 27, 1981.

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