Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1996-05-10
1998-11-10
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424641, 424650, A61K 716, A61K 3330, A61K 31315, A61K 3132
Patent
active
058339523
DESCRIPTION:
BRIEF SUMMARY
This application is filed pursuant to 35 USC S. 371 as a United States National Phase Application of International Application No. PCT/ED 94/03027 filed Sep. 9, 1994 which claims priority EPO 93307329.8 filed Sep. 16, 1993.
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the use of stannous compounds alone or in combination with zinc compounds as effective agents against bad breath and to the use of oral compositions such as dentifrices, mouthwashes, gels, subgingival rinse compositions, toothpastes, toothpowders, chewing gum, prophylactic pastes, lozenges, flosses, toothpicks comprising a stannous compound, either alone or in combination with a zinc compound to combat bad breath (malodour).
2. The Related Art
In the prior art several proposals have been made to combat bad breath (malodour). Many of these proposals have however not resulted in a reasonably effective composition against bad breath (malodour). One of the few really effective oral compositions is based upon the use of a zinc compound. E.g. in U.S. Pat. No. 4,689,214 and EP-A-0,074,082 oral care products are described which contain a zinc salt and a fluoride, such products having anti-malodour properties. The fluoride can be any of many examples of fluorides, including stannous fluoride. There is, however, no disclosure that the stannous compound as such is the effective agent. It is clear that only zinc was intended to function as effective agent against malodour in combination with fluoride.
Oral compositions which comprise a stannous compound, either alone or in conjunction with a zinc compound, are disclosed in EP-A-0426213, EP-A-0514966, EP-A-0417833 and WO-A-9307852, but these references do not disclose or teach the use of stannous compounds as active agent against bad breath.
SUMMARY OF THE INVENTION
It has now been found that a stannous compound when used alone or in combination with a zinc compound provides an improved anti-bad breath efficacy. Volatile sulphur compounds are considered to be mainly responsible for malodour and bad breath. These may originate from saliva, or from the oral cavity or even the stomach. We have found that stannous compounds are very effective in reducing the level of these volatile sulphur compounds. Not only the effectiveness of the stannous compound alone or particularly in combination with a zinc compound for reducing the level of these volatile sulphur compounds was surprising, but also the long term activity of malodour-inhibition achieved by regular application of an oral composition comprising the active agent(s) according to the present invention was found to be totally unexpected.
DETAILED DESCRIPTION
The stannous compound, suitable for use in the present invention, can be any stannous compound with inorganic or organic counter ions. It can be a highly soluble stannous salt, or it can be a sparingly soluble stannous salt. Highly soluble stannous salts are e.g. stannous fluoride, stannous chloride, stannous chloride fluoride, stannous acetate, sodium stannous fluoride, potassium stannous fluoride, stannous hexafluorozirconate, stannous sulfate, stannous tartrate, stannous gluconate, disodium monostannous citrate, etc. Of these highly soluble stannous salts stannous fluoride is the preferred stannous salt.
Sparingly soluble stannous salts are e.g. stannous pyrophosphate, stannous metaphosphate, stannous oxalate, stannous phosphate, distannous citrate, etc. Stannous pyrophosphate is a preferred sparingly soluble stannous salt. Mixtures of various highly soluble stannous salts may also be used, as well as mixtures of various sparingly soluble stannous salts and mixtures of highly and sparingly soluble stannous salts. A preferred mixture is the mixture of stannous fluoride and stannous pyrophosphate.
Although highly soluble stannous salts can be used in the present invention, they tend to be not sufficiently stable upon storage. The stannous ions, dissolved in an aqueous solution tend to be converted therein to inert tin compounds, which do not provide fo
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Grigor Janet
Raven Stephen John
Chesebrough-Pond's USA Co. Division of Conopco, Inc.
Honig Milton L.
Rose Shep K.
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