Oral composition containing salicylanilide antibacterial agent

Details Oral composition containing salicylanilide antibacterial agent Oral composition containing salicylanilide antibacterial agent

1993-06-11

1994-01-04

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

Ammonia, amine, or derivative thereof

424 49, A61K 716, A61K 722

Patent

active

052758052

ABSTRACT:
An antiplaque oral composition such as a gel, paste or mouthrinse which is comprised of a vehicle having incorporated therein as the antiplaque agent an effective amount of an antibacterial salicylanilide compound and a surfactant mixture of an anionic surfactant, a polyoxyethylene/polyoxypropylene block copolymer and a taurate salt, the pH of the composition being adjusted to a pH of at least 8.0. An antibacterial-enhancing agent such as an anionic polymeric polycarboxylate which enhances the delivery of the salicylanilide compound to and retention on oral tissue surfaces is optionally incorporated in the composition to improve the efficacy of the salicylanilide compound.

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