Oral composition containing particles comprising an active subst

Details Oral composition containing particles comprising an active subst Oral composition containing particles comprising an active subst

1992-03-25

1994-02-22

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424491, 424492, 424493, 424494, 424495, 424496, 424497, 424499, 424500, 424501, 514937, H61K 916

Patent

active

052885003

ABSTRACT:
An oral composition which is adapted to be dispersed in an aqueous carrier substantially immediately prior to administration comprises a multiplicity of particles comprising an active substance, the particles being combined with one or more gelling or swelling agents capable of forming a viscous medium around the particles in an aqueous carrier as well as being provided with a masking surface layer when dispersed in the aqueous carrier. This serves to mask uneven surfaces on the particles and prevent them from adhering to oral mucosa when the composition is ingested and thus makes it easier to administer large dosages of an active substance. The masking surface layer is preferably provided by an increased viscosity of the viscous medium in the immediate vicinity of the particles relative to the viscosity of the surrounding aqueous carrier.
A ready-to-use composition is prepared by mixing the composition with an aqueous carrier substantially immediately prior to administration of the composition.

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patent: 4886669 (1989-12-01), Ventouras

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