Drug – bio-affecting and body treating compositions – Dentifrices
Patent
1995-12-27
1998-01-27
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Dentifrices
424 50, 424 58, A61K 716, A61K 726, A61K 728
Patent
active
057119376
DESCRIPTION:
BRIEF SUMMARY
This is a 371 PCT/JP94/01019 filed Jun. 24, 1994.
FIELD OF THE INVENTION
This invention relates to an oral composition containing an antibody which is effective for the prevention or treatment of dental caries and peridontal diseases and more particularly, to such an oral composition which allows the antibody to exert its effect satisfactorily even after long-term shelf storage and presents a pleasant feel on use.
BACKGROUND OF THE INVENTION
Research has been done in the past to blend an antibody in dentifrices and other oral compositions as an active ingredient for preventing dental caries, the antibody having specific interaction with Streptococcus mutans bacterium and being effective for prohibiting adhesion of the bacterium to the dental surface and formation of dental plaque.
Research has also been done to blend an antibody in dentifrices and other oral compositions as an active ingredient for preventing periodontal diseases, the antibody having specific interaction with periodontal disease associated bacteria and being effective for suppressing colonization of the bacteria in the oral cavity.
However, there is a problem that the above-mentioned antibodies tend to be deactivated under the influence of anionic surfactants in the oral compositions. Thus, various studies have been made on the technique for blending antibodies in a stable manner.
Additionally the oral compositions must have a pleasant feel on use since they are used in the oral cavity. Therefore, various flavor components must be blended to improve the feel on use depending on a particular type of consumers' favorite taste or the like although there arises a problem that many flavor components have undesirable influence on the stability of antibodies.
Therefore, it is desired to develop an oral composition which is improved in antibody stability and feel on use.
DISCLOSURE OF THE INVENTION
An object of the present invention is to provide an antibody-containing oral composition which is improved in antibody stability, allows the antibody to exert its effect satisfactorily even after long-term shelf storage and presents a pleasant feel on use.
Making extensive investigations to attain the above object, the inventors have found that by using a flavor component selected from the group consisting of carvone, anethole, cineole, methyl salicylate, eugenol, ethyl butyrate, and cinnamic aldehyde, and l-menthol in combination in a weight ratio of from 1:9 to 8:2 in an oral composition containing an antibody selected from the group consisting of a serum antibody, egg yolk antibody and milk antibody, quite unexpectedly, there is obtained an oral composition which maintains the antibody stable and even after long-term shelf storage, allows the antibody to retain its activity satisfactorily and to fully exert its effect, and provides a pleasant feel on use. The present invention is predicated on this finding.
Therefore, the present invention provides an oral composition characterized in that a flavor component selected from the group consisting of carvone, anethole, cineole, methyl salicylate, eugenol, ethyl butyrate, and cinnamic aldehyde, and l-menthol are blended in a weight ratio of from 1:9 to 8:2 in an oral composition containing an antibody selected from the group consisting of a serum antibody, egg yolk antibody and milk antibody.
The oral composition of the invention is prepared as dentifrices including toothpaste, wet toothpowder, toothpowder, and liquid dentifrice, liquid mouth refreshers such as mouthwash, solid mouth refreshers such as troche, chewing gum, and the like. The composition contains an antibody selected from the group consisting of serum antibodies, egg yolk antibodies and milk antibodies as an active ingredient and further contains a flavor component selected from the group consisting of carvone, anethole, cineole, methyl salicylate, eugenol, ethyl butyrate, and cinnamic aldehyde, and l-menthol combined in a weight ratio of from 1:9 to 8:2.
The antibody used herein may be any of the antibodies corresponding to various
Gomi Tetsuo
Harada Yoshihiro
Morishima Midori
Nishida Yasukuni
Ohta Maimi
Lion Corporation
Rose Shep K.
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