Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1997-04-08
1999-11-09
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424489, 424494, 424486, 424487, 424464, A61K 916, A61K 950
Patent
active
059809515
ABSTRACT:
An oral drug dosage unit, for administration to a patient, having active drug, and an effective diameter and surface composition sufficient for the unit to be transported from the stomach into the duodenum following substantially complete emptying of chyme from the stomach into the intestine and prior to release of active drug from the unit, wherein the active drug has an absorption rate that is substantially affected by the coinciding presence of food in the stomach, the effective diameter of the unit prevents gastric emptying of the unit prior to gastric emptying of chyme, and the surface composition is an enteric coating which prevents release of the active drug in the stomach and allows release of the active drug in the intestine.
REFERENCES:
patent: 3689634 (1972-09-01), Kliment et al.
patent: 4976949 (1990-12-01), Meyer et al.
patent: 5171580 (1992-12-01), Iamartino et al.
patent: 5206373 (1993-04-01), Chung et al.
patent: 5227490 (1993-07-01), Hartman et al.
patent: 5374430 (1994-12-01), Newton et al.
patent: 5446056 (1995-08-01), Wityak et al.
patent: 5470849 (1995-11-01), Callahan et al.
Lui et al., Journal of Pharmaceutical Sciences, "Application of a Radiotelemetric System to Evaluate the . . . ", vol. 75, No. 5, pp. 469-474 (1986).
Dressman et al., Journal of Pharmaceutical Sciences, "Radiotelemetric Mehod for Evaluating Enteric Coatings in Vivo", vol. 73, No. 7, pp. 935-938 (1984).
Chan et al., Pharmaceutical Research, "Application of Radiotelemetric Technique in Evaluating Diclofenac Sodium. . .", vol. 7, No. 10, pp.. 1026-1032 (1990).
Mojaverian et al., Pharmaceutical Research, "Mechanism of Gastric Emptying of a Nondisintegrating. . . ", vol. 8, No. 1, pp. 97-98 (1991).
Mojaverian et al., Gastroenterology "Estimation of Gastric Residence Time of the Heidelberg Capsule . . . ", vol. 89, pp. 392-397 (1985).
Russell et al., aaps American Association of Pharmaceutical Scientists, "Upper Gasrointestinal PH in 80 Healty, Older Subjects . . . ", Abstract Reproduction Form, (1991).
Dressman, Pharmaceutical Research, "Upper Gastrointestinal (GI) pH in Young, Healthy Men and Woman", vol. 7, No. 7, pp. 756-761 (1990).
Asgharnejad Mandana
Gardner Colin R.
Benston, Jr. William E.
Merck & Co. , Inc.
Page Thurman K.
Parr Richard S.
Winokur Melvin
LandOfFree
Oral coated active drugs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oral coated active drugs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oral coated active drugs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1452219