Oral care compositions comprising certain substituted diphenyl e

Details Oral care compositions comprising certain substituted diphenyl e Oral care compositions comprising certain substituted diphenyl e

1995-04-28

1996-11-26

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Dentifrices

Phosphate compound containing

424 49, A61K 716

Patent

active

055782957

ABSTRACT:
The subject invention encompasses methods and compositions comprising phosphate derivatives of triclosan for treating or preventing dental plaque, gingivitis or periodontal disease, of the oral cavity in humans or lower animals.

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patent: 4894220 (1990-01-01), Nabi
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Kamat, J. Ind. Dent. Asso. 50, 171-175 (1978.
Science vol. 253, Sep. 6, 1991. 1095-96 Miller.
Noguchi. Chem Absts 84, 1976, #135297g.
Miglani, D. C., E. Raghupathy, A. Rajasekher and S. Shyamala, "Studies on Salivary Phosphatases III. On the Possible Relation Between Salivary Alkaline Phosphatase Activity and Gingival Inflammation," J. Periodontol, Jul. 1974, 45(7), 511-13.
Kamat, N. V., "Biochemical Aspects of Periodontal Diseases: II, The Possible Significance of Calcium Phosphorous and Alkaline Phosphatase in Human Saliva," Journal Indian Dent. Asso. 50, 171-175, 1978 (month not known).
Saxton, C. A., B. Svatun and A. M. Lloyd, "Antiplaque Effects and Mode of Action of a Combination of Zinc Citrate and a Nonionic Antimicrobial Agent", Scand. J. Dent. Res, Jun. 1988, 96:212-7.
Jenkins, S., M. Addy and R. Newcombe, "Studies on the Effect of Toothpaste on Plaque Regrowth, (II). Triclosan With & Without Zinc Citrate Formulations," J. Clin. Periodontol, Jul. 1989, 16(6), 385-7 (Eng).
"A Better Way to Make the Medicine Go Down" Research News, Science, vol. 253, Sep. 6, 1991, pp. 1095-1096.
Jenkins, S., M. Addy and R. Newcombe, "Triclosan and Sodium Lauryl Sulphate Mouthrinses (II). Effects of 4-Day Plaque Regrowth," J. Clin. Periodontol Feb. 1991; 18: 145-48.
Marsh, P. D., "Dentrifrices Containing New Agents For the Control of Plaque and Gingivitis: Miscorbiological Aspects," J. Clin. Periodontol, Jul. 1991, 18:462-67.
Lindhe, J., "Triclosan/copolymer/fluoride dentifrices: A new technology for the prevention of plaque, calculus, gingivitis and caries", Am. J. Dent., 3:S1-S72 (Sep. 1990).
Van der Ouderaa, F. J. and Cummins, D., "Delivery Systems for Agents in Supra- and Sub-gingival Control", J. Dent. Res., 68:1617-24 (Nov. 1989).

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