Oral bilirubin therapy

Details Oral bilirubin therapy Oral bilirubin therapy

1990-10-01

1993-04-06

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Stabilized enzymes or enzymes complexed with nonenzyme

424 944, 424 945, 424489, 435174, 435177, 435178, 435179, A61K 3750, A61K 3752, A61K 914, C12N 1100

Patent

active

052001814

ABSTRACT:
Levels of bilirubin in mammalian serum are controlled by administering to the mammalian intestinal tract a substance (a "bilirubin deactivator") that converts unconjugated bilirubin into nontoxic, physiologically compatible products, thereby reducing reabsorption of unconjugated bilirubin in enterohepatic circulation. Useful bilirubin deactivators include those which specifically adsorb the bilirubin and are excreted, and "bilirubin conversion enzymes", i.e., enzymes that operate on the unconjugated bilirubin substrate to yield products that are physiologically compatible in that they are not reabsorbed, or, if reabsorbed, they are nontoxic in the blood stream.

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Lavin et al., Science 230:(4725):543 (1985).
Odell et al., Ped. Res., 17, 810 (1983).
Poland and Odell, Proc. Soc. Exp. Biol. Med. 146:1114 (1974).

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