Oral anti-diabetic pharmaceutical forms and the preparation ther

Details Oral anti-diabetic pharmaceutical forms and the preparation ther Oral anti-diabetic pharmaceutical forms and the preparation ther

1984-05-31

1987-11-24

Brown, J. R.

Expansible chamber devices

424 83, 514255, 514309, 514378, 514412, 514471, 514584, 514861, A61K 3179, A61K 31745, A61K 31495, A61K 3147

Patent

active

047088680

ABSTRACT:
This invention is directed to novel galenic preparation forms for providing an oral anti-diabetic agent having an improved release of active substance and to processes for producing these preparation forms. The pharmaceutical compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the anti-diabetically active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. The solution is applied to a water-insoluble carrier, the solvent is evaporated, and the residue is further processed to yield the various preparation forms.

REFERENCES:
patent: 3668215 (1972-06-01), Plumpe et al.
patent: 3669966 (1972-06-01), Ambrogi et al.
patent: 3708486 (1973-01-01), Ruffer et al.
patent: 3883648 (1975-05-01), Ross et al.
patent: 4430339 (1984-02-01), Eisteffer et al.

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