Oral anti-diabetic pharmaceutical compositions and the preparati

Details Oral anti-diabetic pharmaceutical compositions and the preparati Oral anti-diabetic pharmaceutical compositions and the preparati

1987-09-30

1989-10-10

Rollins, John W.

Drug, bio-affecting and body treating compositions

Lymphokine

424 83, 514315, 514408, 514568, A61K 3179, A61K 31745, A61K 31445, A61K 3140

Patent

active

048730807

ABSTRACT:
Galenic compositions containing an oral antidiabetic agent and having an improved release of active substance as well as processes for producing these compositions are provided. The pharmaceutical compositions are characterized in that the onset of the activity and the duration of activity are adapted to the particular needs of diabetics with regard to proper control of metabolism and the associated proper release of insulin. A basic or acidic excipient in a solvent is added to the anti-diabetically active substance in a quantity such that the active substance is made soluble, and then a solubilizing agent is added. The solution is applied to a water-insoluble carrier, the solvent is evaporated, and the residue is further processed to yield the various compositions.

REFERENCES:
patent: 4696815 (1987-09-01), Schepky et al.
patent: 4708868 (1987-11-01), Brickl et al.

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