Oral and dental hygiene preparations

Details Oral and dental hygiene preparations Oral and dental hygiene preparations

1987-03-02

1989-04-11

Moskowitz, Margaret

Drug, bio-affecting and body treating compositions

Dentifrices

Ammonia, amine, or derivative thereof

424 49, 424 57, 424 55, 514900, 514901, 514835, A61K 722, A61K 716, A61K 724

Patent

active

048205079

ABSTRACT:
Oral and dental hygiene preparations containing quaternary ammonium compounds of the formula ##STR1## wherein R.sup.1 is an n-alkyl group, preferably containing from 8 to 12 carbon atoms, R.sup.2 is hydrogen, a CH.sub.3 -group or a CH.sub.2 OH-group and R.sup.3 is a CH.sub.3 -group or a group of the formula --CH.sub.2 --CH(OH)--R.sup.2, A is an inorganic or organic acid anion and n is the basicity of the anion. The quaternary ammonium compounds of formula I can have a plaque inhibiting effect and show only slight antimicrobial activity. R.sup.1 is preferably an n-decyl group, R.sup.2 is hydrogen and R.sup.3 is a CH.sub.3 -group or a 2-hydroxyethyl group. The oral and dent al hygiene preparations also preferably contain fluorides and/or organophosphonates as the anion A.

REFERENCES:
patent: 3277118 (1966-10-01), Schmid et al.
patent: 3369046 (1968-02-01), Kaniecki
patent: 3488419 (1970-01-01), McCune et al.
patent: 3703583 (1972-11-01), Martin
patent: 3988443 (1976-10-01), Ploger
patent: 4492802 (1985-01-01), Rutzen et al.

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