Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1995-01-30
1997-05-13
Housel, James C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
4241841, 424482, 424464, 424422, 424497, A61K 3900, A61K 932, A61K 916, A61F 1300
Patent
active
056290012
ABSTRACT:
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.
REFERENCES:
patent: 4016254 (1977-04-01), Seager et al.
patent: 4017647 (1977-04-01), Ohno et al.
patent: 4348384 (1982-09-01), Horikoshi et al.
patent: 4469677 (1984-09-01), Michael et al.
patent: 4507276 (1985-03-01), Tencza et al.
patent: 4642232 (1987-02-01), Yman et al.
patent: 4704295 (1987-11-01), Porter et al.
patent: 4798844 (1989-01-01), Fujita et al.
patent: 4820627 (1989-04-01), McGeehan et al.
patent: 4874613 (1989-10-01), Hsiao et al.
patent: 4900557 (1990-02-01), Dell et al.
patent: 4920209 (1990-04-01), Davis et al.
patent: 4946945 (1990-08-01), Wojdani
patent: 4981693 (1991-01-01), Higashi et al.
patent: 4996058 (1991-02-01), Sinnreich et al.
patent: 5049390 (1991-09-01), Wojdani
patent: 5202159 (1993-04-01), Chen et al.
patent: 5236713 (1993-08-01), Wato et al.
Sayegh, M.H. et al., Induction of Immunity and Oral Tolerance with Polymorphic Class II Major Histocompatibility Complex in the Rat, Proc. Natl. Acad. Sci. USA (1992) 89:7762-7766.
Ewguall, E., et al., Enzyme Linked Immunosorbant Assay ELISA III Quantitation of Specific Antibodies by Enzyme Labeled Anti-immunoglobulin in Antigen Coated Tubes, J. Immunol. (1972) 109:129.
Van Metre, T.E., Jr., et al., Immunotherapy for Aeroallergen Disease in Middleton, E. Jr., Reed, C.E., Ellis, F.F., Adkinson, N.R. Jr., (eds): Allergy Principles and Practice, Ed. 3, vol. II, St. Louis, CV Moshy, (1988) p. 1336.
Creticos, P.S., Immunologica Change Associated with Immunotherapy, Immunol. Aller. Clin. N. American, (1992) 12:13.
Hoffman, D., The Use and Interpretation of RAST to Stinging Insert Venom, Ann. Allergy, (1979) 43:224.
Eldridge, J.H. et al., Controlled Vaccine Release in the Gust-associated Lymphoid Tissues. I. Orally Administered Biodegradable Microcapsules Target to the Peyer's Patches, J. Controlled Release, (1990) 11:205-214.
O'Hagan, D.T., et al., Biodegradable Microparticle as Controlled Release Antigen Delivery System, Immunology (1991) 73:239-242.
Mowat, A.M., The Regulation of Immune Responses to Dietary Protein Antigens, Immunol. Today (1987) 8:93.
Adorini, L., et al., Approaches Toward Peptide Based Immunotherapy of Autoimmune Diseases, Springer Seminars Immunopathology (1992) 14:187-199.
Wong, George K., Development of Novel Oral Enteric-Coated Aquaculture Vigro Vaccines (1990) (unpublished Ph.D. thesis, Oregon State University, available from UMI Dissertation Services).
Moldoveanu et al., 1993. J. Infect. Disease 167:84-90.
Wheeler et al., 1987. Int. Arch. Allergy Appl. Immunol. 83(4):354-8.
Lai, 1985. Diss. Abs. Int. 49(10B):4254.
Waldman et al., 1986. Amer. J. Med. Sci. 292(6):367-71.
Fukumori, et al., 1988(a). Chem. Pharm. Bull. 36(12):4927-32.
Fukumori, et al., 1988. Chem. Pharm. Bull. 36(8):3070-78.
Langer, et al., 1990. Science 249:1527-1533.
Murray, et al., 1990. Aus. J. Hospital Pharm. 20(3):235-38.
Childers et al., Regional Immunology vol. 3(6), 289-296, 1990/1991).
Langer, 1990, New Methods of Drug delivery. Science 249: 1527-1533.
Murray et al. 1990. Gastric Residence times of Enteric Coated Dosage forms-A Review. Aus. J. Hosptial Pharm. 20(3):235-38.
Lai, 1985, Design and evaluation of waterbased pseudolatex enteric coating systems. Dissabs. vol. 49 No. 10B p. 4254.
Fukumori et al., 1988(A), Coating of pharmaceutical powders by fluidized bed process. IV. Softening . . . Chem. Pharm. Bull. 36(12):4927-32.
Fukumori et al 1988, Coating of pharmaceutical powders by fluidized bed process. III. Aqueous . . . Chem. Pharm. Bull. 36(8):3070-78.
Wong 1990 Development of novel oral enteric-coated aqua culture vibrio vaccines . . . Dissabs. Int. 52(5B):2519.
Litwin Allen
Michael J. Gabriel
Housel James C.
Minnifield N. M.
University of Cincinnati
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