Oral administration of therapeutic proteins for treatment of aut

Details Oral administration of therapeutic proteins for treatment of aut Oral administration of therapeutic proteins for treatment of aut

1995-06-05

1998-07-21

Minnifield, Nita

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4242041, 424422, 424497, 424451, 424464, 424482, 4242781, 514 2, 514 8, 514 21, 514825, A61K 3900, A61K 916, A61K 1300, A61K 3912

Patent

active

057831939

ABSTRACT:
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process.

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