Oral administration of pneumococcal antigens

Details Oral administration of pneumococcal antigens Oral administration of pneumococcal antigens

1996-05-30

1999-12-21

Housel, James C.

Chemistry: molecular biology and microbiology

Vector, per se

4242441, C12N 1500, A61K 3909

Patent

active

060048026

ABSTRACT:
Oral or peroral administration, including intragastrically, of killed whole pneumococci, lysate of pneumococci and isolated and purified PspA, as well as immunogenic fragments thereof, particularly when administered with an adjuvant such as cholera toxin provides protection in a host, animal or human, against pneumococcal infection, including colonization, and systemic infection, such as sepsis. The ability to elicit protection against pneumococcal colonization in a host prevents carriage among immunized individuals, which can lead to elimination of disease from the population as a whole.

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Kuromo et al Abstracts of the Fourteenth Midwinter Research Meeting Assoc. for Resin Otol. p. 56 190 178, 19.
McDaniel et al Infection and Immunity 59:222-228, 1991.

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