Oral administration of immunologically active biomolecules and o

Details Oral administration of immunologically active biomolecules and o Oral administration of immunologically active biomolecules and o

1995-01-20

1997-01-07

Housel, James C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

424464, 424482, 424497, 424422, 424451, 4242781, 4242751, 4242741, A61K 3900, A61K 916, A61K 1300, A61K 4500

Patent

active

055914330

ABSTRACT:
An orally administrable therapeutic protein is provided by combining the therapeutic protein with a stabilizing agent in an aqueous solution. The solution is coated onto nonpareils and microencapsulated with a water emulsifiable enteric coating composition. The microcapsules are orally administered. The coating protects the protein as it passes through the stomach. Upon reaching the small intestines, the basic pH of the intestinal juices will dissolve the coating, allowing the protein to be released and induce antigen specific immune response which has the specificity of the native molecule. The stabilizing agent protects the therapeutic protein from denaturation during the encapsulation process. In addition to being immunogenic, when administered orally, encapsulated allergen has a therapeutic effect in the treatment of human allergies.

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