Oral administration of antigens

Details Oral administration of antigens Oral administration of antigens

1992-07-20

1994-10-04

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Specially adapted for ruminant animal

424426, 424486, 424487, 424435, 424434, 4242551, 4242341, 4242801, 424823, A61K 3900, A61K 4734, A61K 916, A61K 922

Patent

active

053524489

ABSTRACT:
An oral vaccine formulation is provided for stimulation of an immune response in gut-associated lymphoid tissues. The formulation comprises an enzymatically degradable antigen in a hydrogel matrix. In ruminant species, the vaccine formulation, upon oral administration, is formed to pass through the rumen without substantial hydration and then into the post-ruminal portion of the digestive tract where the antigen is released for contact with the gut-associated lymphoid tissue.

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Heller et al. "Controlled Release of Water Soluble Macromolecules from Bioerodible Hydrogels" Biomaterials 4(4) 1983, pp. 262-266.

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