Oral absorption enhancement of carboxylic acid pharmaceuticals u

Details Oral absorption enhancement of carboxylic acid pharmaceuticals u Oral absorption enhancement of carboxylic acid pharmaceuticals u

1982-06-07

1984-10-30

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Combination of antigens from multiple bacterial species

2602391, 2602452R, 2602452T, 2602454, 424232, 424246, 424290, 424291, 424278, 544 21, 544 29, 546189, 548194, 548196, 548344, 548494, 548500, 548531, 548532, 548533, 548535, 549229, A61K 31545, A61K 31665, C07D49900, C07D50146, C07D31724, C07D27740

Patent

active

044799470

ABSTRACT:
The (5-R-2-oxo-1,3-dioxolen-4-yl)methyl moiety: ##STR1## wherein R is loweralkyl of 1-6 carbon atoms, especially methyl or t-butyl; when utilized as an ester on a pharmaceutical having a carboxylic acid functionality, enhances oral absorption of the pharmaceutical. This effect is applicable to a broad range of pharmaceutically active substances, including antibiotics, and antihypertensives as well as other classes of therapeutic agents.

REFERENCES:
patent: 3873521 (1975-03-01), Ekstrom et al.
patent: 3939270 (1976-02-01), Ekstrom et al.
patent: 4109084 (1978-08-01), Gordon
patent: 4342693 (1982-08-01), Sakamoto et al.

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