Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1997-12-09
2000-07-11
Chin, Christopher L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
385 12, 385129, 422 55, 422 58, 422 8205, 422 8206, 422 8207, 422 8208, 422 8209, 422 8211, 435 721, 4352871, 4352872, 4352887, 435808, 436164, 436172, 436518, 436527, 436536, 436805, 436519, G01N 33543, G01N 33554
Patent
active
060871148
ABSTRACT:
A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where binding of the antigen to the antibodies results in an increase in calcium concentration in the cytosol of the cell, the cell further having a emitter molecule which, in response to the increased calcium concentration in the cytosol, emits a photon; (2) a liquid medium for receiving the antigen and in which the cell is immersed; and (3) an optical detector arranged for receiving the photon emitted from the cell.
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Chin Christopher L.
Massachusetts Institute of Technology
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