Optionally substituted 6,8-quinolines

Details Optionally substituted 6,8-quinolines Optionally substituted 6,8-quinolines

1993-03-31

1995-10-03

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514314, 514826, 546107, 546173, A61K 3147, C07D21504, C07D21512

Patent

active

054552524

ABSTRACT:
A compound of the formula ##STR1## wherein: R.sup.1 is independently selected from hydrogen, lower-alkyl, cycloalkyl, cycloalkyl lower-alkyl, lower-alkoxy, formyl, (lower-alkyl)-hydroxylmethyl, aryl, benzyl, arylmethyl, pyridylmethyl,

REFERENCES:
patent: 4563460 (1986-01-01), Kuhla et al.
Price, et al., "J. Amer. Chem. Soc.", vol. 68, No. 12, pp. 2589-2592, 1946.
Ollis, W. D. et al., "Heterocyclic Mesomeric Betaines. Part 2. Synthesis of a Hetero Derivative of the Benzo[b]phenalenide Anion", J. Chem. Soc. Perkin Trans. I, (1989), No. 5, pp. 953-956.
Hassanaly, P. et al., "Homolytic Aromatic Substitution by Heterocyclic Free Radicals. Reaction of 3-Quinolyl and 8-Quinolyl Radicals with Aromatic Compounds", J. Heterocyclic Chem., Aug. 1975, vol. 12, pp. 703-704.
Wommack, J. B. et al., "The Synthesis of Quinoline- and Isoquinolinecarboxaldehydes", J. Heterocyclic. Chem., Apr. 1969, vol. 6, No. 2, pp. 243-245.
Honel, M. et al., "Selectivity in the Hydrogenation of 6- and 8-Substituted-quinolines", J. Chem. Soc. Perkin Trans. I, (1980), No. 9, pp. 1933-1939.

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