Optionally substituted (3.beta.-9,10-didehydro-2,3-dihydro ergol

Details Optionally substituted (3.beta.-9,10-didehydro-2,3-dihydro ergol Optionally substituted (3.beta.-9,10-didehydro-2,3-dihydro ergol

1987-08-31

1989-01-17

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 67, 546 69, A61K 3148, C07D45700

Patent

active

047988347

ABSTRACT:
A therapeutic method employing 2,3-dihydroergolines is disclosed. Said method enhances serotonergic function in the nervous system of a mammal in need thereof, thereby finding application in serotonin-mediated physiological manifestations including memory, depression, anxiety, pain and appetite. Also disclosed are pharmaceutical compositions containing said 2,3-dihydroergolines in admixture with pharmaceutically acceptable diluents and carriers.

REFERENCES:
patent: 3113133 (1963-12-01), Hoffman et al.
patent: 3580916 (1971-05-01), Garbrecht
patent: 3992385 (1976-11-01), Bach et al.
patent: 4166182 (1979-08-01), Kornfeld
patent: 4201862 (1980-05-01), Kornfeld
patent: 4348391 (1982-09-01), Stutz et al.
Nakahara et al., Chem. Pharm. Bull. 25 (7), 1756-1763 (1977).
Sauer et al., CA 105-43137d.
Goodman et al., The Pharmaceutical Basis of Therapeutics 7th edition, pp. 247-256, pp. 628-635.
Kiguchi et al., "Total Synthesis of Ergot Alkaloid (.+-.) Fumigaclavine B", Heterocycles 23 (8), 1925-1928 (1985).
Ninomiya et al., "Dehydrogenation with Phenylseleninic Anhydride in the Total Synthesis of Ergot Alkaloids", Tetrahedron Letters, 26, No. 35, 4187-4190 (1985).

Affiliated with

Also associated with

Rating

Optionally substituted (3.beta.-9,10-didehydro-2,3-dihydro ergol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optionally substituted (3.beta.-9,10-didehydro-2,3-dihydro ergol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optionally substituted (3.beta.-9,10-didehydro-2,3-dihydro ergol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2413638