Optionally N-substituted aminodesoxy-1.4;3.6-dianhydrohexitol de

Details Optionally N-substituted aminodesoxy-1.4;3.6-dianhydrohexitol de Optionally N-substituted aminodesoxy-1.4;3.6-dianhydrohexitol de

1981-07-20

1983-11-01

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544377, 546197, 548526, 549464, C07D49304

Patent

active

044131224

ABSTRACT:
Aminodesoxy-1.4;3.6-dianhydrohexitol derivatives of the general formula I, ##STR1## wherein R.sup.1 and R.sup.2, in each case independently of one another, signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms or wherein R.sup.1 signifies a hydrogen atom and R.sup.2 an adamant(1)yl radical or wherein R.sup.1 and R.sup.2, together with the nitrogen atom to which they are attached, (a) signify the residue of a cyclic, non-aromatic secondary amine possibly containing a further hetero atom or (b) the aden(9)yl radical possibly mono- or disubstituted on the 6-amino group or (c) the 6-alkylmercaptopurin(9)yl radical or (d) the theophyllin(7)yl radical or (e) the 6-chloropurin-9-yl radical or wherein R.sup.1 signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms and R.sup.2 an .omega.-theophyllin(7)ylalkyl radical or an .omega.-theobromin-1-ylalkyl radical or an .omega.-(N,N'-di-lower alkyl-substituted xanthin-N"-yl)alkyl radical, whereby "lower alkyl" signifies an alkyl group with 1 to 5 C-atoms, or an .omega.-adenin-9-ylalkyl radical, whereby the alkyl radical has 2 to 7 C-atoms and can be straight-chained or branched, and wherein R.sup.3 signifies a hydrogen atom, a methanesulphonyl or toluenesulphonyl group, as well as their acid-addition salts.
Processes for the preparation of said compounds and use of said compounds as reactive intermediate products for the preparation of the corresponding pharmacologically-effective amino-desoxy-1.4;3.6-dianhydrohexitol nitrates.

REFERENCES:
Cope et al., J. Amer. Chem. Soc., vol. 78 (1956), pp. 3177-3182.

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