Optimum calibration frequency determination

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36457101, 356346, G06F 1520

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active

053964403

ABSTRACT:
One aspect of the invention is a method for determining whether systematic biases are present in an instrument. The method involves first obtaining a series of replicates produced by an instrument. Then, a Fourier Transform is performed on that data, thereby generating a secondary spectrum which indicates the frequency characteristics of the data. This secondary spectrum is then compared to secondary spectra obtained in a similar matter from a series of random number sets to determine whether variations observed are within an expected range as defined by the random number series.
Another aspect of the invention is a method for determining an optimum frequency at which the instrument should be calibrated. This method comprises obtaining a set of multivariate data as before, and treating every xth data point as a calibration point and adjusting the values of the points following the calibration point accordingly. A Fourier Transform is then calculated as before. Different values for x are tried, and an optimum calibration frequency is deemed to be a value for x in a region which produces a point which is most similar to the distribution of points corresponding to the series of random number sets.

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E. A. Yfantis, et al., "Optimum Frequency of Calibration Monitoring", Chemometrics and Intelligent Laboratory Systems, vol. 3, pp. 39-43 (1988).
H. C. Smit, "The Use of Kalman Filtering and Correlation Techniques in Analytical Calibration Procedures" Jnal. of Research of the Nat'l Bureau of Standards, vol. 90, No. 6, pp. 441-450, (1985).

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