Optimizing glycan processing in plants

Multicellular living organisms and unmodified parts thereof and – Method of introducing a polynucleotide molecule into or... – The polynucleotide alters carbohydrate production in the plant

Reexamination Certificate

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C800S298000, C800S288000, C435S320100, C435S468000, C536S023400

Reexamination Certificate

active

08058508

ABSTRACT:
The invention is directed to methods for optimizing glycan processing in organisms (and in particular, plants) so that a glycoprotein having complex type bi-antennary glycans and thus containing galactose residues on both arms and which are devoid of (or reduce in) xylose and fucose can be obtained. The invention is further directed to said glycoprotein obtained and host system comprising said protein.

REFERENCES:
patent: 4956282 (1990-09-01), Goodman et al.
patent: 5202422 (1993-04-01), Hiatt et al.
patent: 5639947 (1997-06-01), Hiatt et al.
patent: 5874271 (1999-02-01), Nishikawa et al.
patent: 5879912 (1999-03-01), Roth
patent: 5939288 (1999-08-01), Thornburg
patent: 5959177 (1999-09-01), Hein et al.
patent: 6046040 (2000-04-01), Nishiguchi et al.
patent: 6054304 (2000-04-01), Taniguchi et al.
patent: 6331418 (2001-12-01), Roth
patent: 6344600 (2002-02-01), Merot et al.
patent: 6388068 (2002-05-01), Satoh et al.
patent: 6602684 (2003-08-01), Umana et al.
patent: 6653459 (2003-11-01), Von Schaewen et al.
patent: 2001/0055584 (2001-12-01), McKenzie et al.
patent: 2002/0174453 (2002-11-01), Danielle et al.
patent: 2004/0072290 (2004-04-01), Umana et al.
patent: 2004/0181827 (2004-09-01), Schaewen
patent: 2007/0214519 (2007-09-01), Fujiyama et al.
patent: 19754622 (1999-06-01), None
patent: 0 351 313 (1990-01-01), None
patent: 0 550 756 (1993-07-01), None
patent: 0 737 745 (1996-10-01), None
patent: 1 243 647 (2002-09-01), None
patent: 2000-245470 (2000-09-01), None
patent: 2000-287692 (2000-10-01), None
patent: WO 87/00865 (1987-02-01), None
patent: WO 92/18537 (1992-10-01), None
patent: WO 94/12646 (1994-06-01), None
patent: WO 95/02683 (1995-01-01), None
patent: WO 95/21248 (1995-08-01), None
patent: WO 97/04122 (1997-02-01), None
patent: WO 98/31826 (1998-07-01), None
patent: WO 98/31828 (1998-07-01), None
patent: WO 99/09187 (1999-02-01), None
patent: WO 99/24584 (1999-05-01), None
patent: WO 99/29879 (1999-06-01), None
patent: WO 99/38987 (1999-08-01), None
patent: WO 99/38990 (1999-08-01), None
patent: WO 99/51185 (1999-10-01), None
patent: WO 00/28792 (2000-05-01), None
patent: WO 00/29603 (2000-05-01), None
patent: WO 00/34490 (2000-06-01), None
patent: WO 00/49153 (2000-08-01), None
patent: WO 00/52136 (2000-09-01), None
patent: WO 01/29241 (2001-04-01), None
patent: WO 01/29242 (2001-04-01), None
patent: WO 01/31044 (2001-05-01), None
patent: WO 01/31045 (2001-05-01), None
patent: WO0131045 (2001-05-01), None
patent: WO 01/49821 (2001-07-01), None
patent: WO 01/49831 (2001-07-01), None
patent: WO 01/62912 (2001-08-01), None
patent: WO 01/64901 (2001-09-01), None
patent: WO 01/81591 (2001-11-01), None
patent: WO 01/82912 (2001-11-01), None
patent: WO 02/00879 (2002-01-01), None
patent: WO 02/057468 (2002-07-01), None
patent: WO 02/007067 (2002-09-01), None
patent: WO 03/001187 (2003-02-01), None
patent: WO 03/007661 (2003-09-01), None
patent: WO 03/007861 (2003-09-01), None
patent: WO 03/007863 (2003-09-01), None
patent: WO 2004/005083 (2004-06-01), None
2000 GenBank Accession AJ277603 Bakker (Provided by Applicant).
Genbank Submission; NIH/NCBI, Accession No. AJ277603. Bakker et al. Apr. 28, 2000.
Genbank Submission; Accession No. Q92074. Shaper J.H. Nov. 1, 1996.
Genbank Submission; Accession No. U19890. Shaper J. H. Aug. 3, 1996.
Genbank Submission; Accession No. BC124813. Aug. 5, 2006.
Genbank Submission; Accession No. Q08B99. Strausberg et al. Oct. 31, 2006.
Aoki et al. Golgi retention of a trans-Golgi membrane protein, galactosyl-transferase, requires cysteine and histidine residues within the membrane-anchoring domain. (1992) Cell Biology 89, 4319-4323.
Asano et al., Growth retardation and early death of beta-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells. EMBO J. Apr. 15, 1997;16(8):1850-7.
Bailey et al. Metabolic engineering of N-linked glycoform synthesis systems in Chinese hamster ovary (CHO) cells (1997) Animal Cell Technology, pp. 489-494.
Bakker et al., Galactose-extended glycans of antibodies produced by transgenic plants. Proc Natl Acad Sci U S A. Feb. 27, 2001;98(5):2899-904.
Bakker et al., AnArabidopsis thalianaCdna complements the N-acetylglucosaminyltransferase I deficiency of CHO Lec1 cells. Biochem Biophys Res Commun. Aug. 11, 1999;261(3):829-32.
Borisjuk et al., Production of Recombinant Proteins in Plant Root Exudates. Nat. Biotechnology 17(5): 466-469 (1999).
Boyd et al. The effect of the removal of sialic acid, galactose and total carbohydrate on the functional activity of Campath-1H (1995) Mol Imm. 32, 1311-8.
Cabanes-Macheteau et al., N-Glycosylation of a mouse IgG expressed in transgenic tobacco plants. Glycobiology. Apr. 1999;9(4):365-72.
Choi et al., Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris. Proc Natl Acad Sci U S A. Apr. 29, 2003;100(9):5022-7. Epub Apr. 17, 2003.
Chrispeels and Faye, The production of recombinant glycoproteins with defined non-immunogenic glycans. In: Transgenic plants: a production system for industrial and pharmaceutical proteins. John Wiley Pub, UK. 1996:99-113.
Colley “Golgi localization of glycosyltransferases: more questions than answers” (1997) Glycobiology 7(1):1-13.
Cousin et al. “Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit.” (1998) J of Clin. Endocrin. and Metab. 83: 245-240.
De Vries et al. Isolation of total and polysomal RNA from plant tissues. (1991) Plant Mol. Biology B6/1-13.
Dieryck et al. Human Haemoglobin from transgenic tobacco (1997) Nature 386, 29-30.
Dinter and Berger, The regulation of cell- and tissue-specific expression of glycans by glycosyltransferases. Adv Exp Med Biol. 1995;376:53-82.
Elbers et al., Influence of growth conditions and developmental stage on N-glycan heterogeneity of transgenic immunoglobulin G and endogenous proteins in tobacco leaves. Plant Physiol. Jul. 2001;126(3):1314-22.
Essl et al., The N-terminal 77 amino acids from tobacco N-acetylglucosaminyltransferase I are sufficient to retain a reporter protein in the Golgi apparatus ofNicotiana benthamianacells. FEBS Lett. Jun. 18, 1999;453(1-2):169-73.
Faye et al Affinity purification of antibodies specific for Asn-linked glycans containing alpha 1—> 3 fucose or beta—> 2 xylose. (1993) Anal Biochem 209, 104-8.
Fischer and Evans, Molecular farming of pharmaceutical proteins. Transgenic Research. 2000;9:279-299.
Fischer et al. Molecular farming of recombinant antibodies in plants. (1999) Biol. Chem. 380:825-839.
Fitchette Laine et al. N-glycans harboring the Lewis a epitope are expressed at the surface of plant cells. (1997) Plan J 12, 1411-7.
Florack et al. Expression of giant silkmoth cecropin B genes in tobacco. (1995) Transgenic Research 4, 132-141.
Fuchs et al., Purification and characterization of microbially expressed neomycin phosphotransferase II (NPTII) protein and its equivalence to the plant expressed protein. Biotechnology (N Y). Dec. 1993;11(13):1537-42.
Fujiyama et al., In vivo conversion of a glycan to human compatible type by transformed tobacco cells. Biochem Biophys Res Commun. Nov. 30, 2001;289(2):553-7.
Gasser and Fraley, Genetically Engineering Plants for Crop Improvement. Science. Jun. 16, 1989;244(4910):1293-1299.
Gleeson “Targeting of proteins to the Golgi apparatus” (1998) Histochem Cell Biol. 109: 517-532.
Gomez and Chrispeels, Complementation of anArabidopsis thalianamutant that lacks complex asparagine-linked glycans with the human cDNA encoding N-acetylglucosaminyltransferase I. Proc Natl Acad Sci U S A. Mar. 1, 1994:91(5):1829-33.
Grabenhorst and Conradt, The cytoplasmic, transmembrane, and stem regions of glycosyltransferases specify their in vivo functional sublocalization and stability in the Golgi. J Biol Chem. Dec. 17, 1999;274(51):36107-16.
Hamilton et al., Production of complex human glycoproteins in yeast. Science. Aug. 29, 2003;301(5637):1244-6.
Handa et al., The alpha 1→3 fucosylation at the penultimate

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