Optimized bacterial host strains of Methylomonas sp. 16a

Details Optimized bacterial host strains of Methylomonas sp. 16a Optimized bacterial host strains of Methylomonas sp. 16a

2007-06-19

2007-06-19

Kerr, Kathleen M. (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing a carotene nucleus

C435S193000, C435S252300, C435S471000, C435S069100, C536S023200

Reexamination Certificate

active

10997844

ABSTRACT:
Methanotrophic bacterial strains are provided that have been optimized for the production of carotenoid compounds through the down-regulation of one or more of the crtN1, ald, crtN2 and crtN3 genes of the carotenoid biosynthetic pathway. The resulting strains lack pigmented C30carotenoid compounds, and show an increase in the production of C40carotenoids. The use of the optimized host strains for the production of the C40carotenoids canthaxanthin and astaxanthin is also described.

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