Optically similar reference samples

Details Optically similar reference samples Optically similar reference samples

2007-04-10

2007-04-10

Wallenhorst, Maureen M. (Department: 1743)

Chemistry: analytical and immunological testing

Optical result

C436S008000, C436S165000, C436S166000, C422S082050, C422S082090, C356S051000, C356S300000, C356S317000, C600S310000, C600S473000, C600S476000

Reexamination Certificate

active

10281576

ABSTRACT:
Systems and methods for establishing and/or maintaining the accuracy of a multivariate calibration model designed for quantitative optical spectroscopic measurement of attributes or analytes in bodily tissues, bodily fluids or other biological samples, which are particularly useful when the spectral absorbance of the attribute or analyte is small relative to the background. The present invention provides an optically similar reference sample to reduce the effect of instrument or environment variation on the measurement capability of the model. The optically similar reference can be a gel composition having scattering particles suspended therein. The reference gel can be directly applied to a spectroscopic instrument sampler, or can be in a container specifically designed for optimal coupling to a spectroscopic instrument.

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