Optically pure compound and a process for its preparation

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546225, A61K 31445

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active

048700860

ABSTRACT:
Optically pure S-(-)-1-propyl-2',6'-pipecoloxylidide hydrochloride monohydrate, with the structural formula ##STR1## a process for the preparation thereof and the use for inducing local anesthesia.

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Tullar, B. F., J. Med. Chem., "Optical Isomers of Mepivacaine and Bupivacaine", 14, 891-892 (1971).
Friberger, P. et al., Acta Pharm. Suecica, "Some Physicochemical Properties of the Racemates and the Optically Active Isomers of Two Local Anaesthetic Compounds", 8, 361-364 (1971).
Aberg, G., Acta Pharmacol et Toxicol. "Toxicological and Local Anaesthetic Effects of Optically Active Isomers of Two Local Anaesthetic Compounds", 31, 273-286 (1972).
Af Ekenstam, B., et al., Acta Chemica Scandinavica, "Local Anaesthetics I. N-Alkyl Pyrrolidine and N-Alkyl Piperidine Carboxylic Acid Amides", 11, 1183-1190 (1957).
Aberg, G., et al., Acta Pharmacol. et Toxicol, "Studies on the Duration of Local Anaesthesia: Structure/Activity Relationships in a Series of Homologous Local Anaesthetics", 41, 432-443 (1977).
Aberg, G., Linkoping University Medical Dissertations, "Studies on Mepivacaine and its Optically Active isomers with Special Reference to Vasaoactive Properties". No. 5, 32 pp. (1972).

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