Optically pure camptothecin analogues

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S283000, C546S014000, C546S041000, C546S048000

Reexamination Certificate

active

07012079

ABSTRACT:
The invention relates in particular to the compounds of general formulain which R1, R2, R3, R4, R5, R6represent various radicals; their use as medicaments and pharmaceutical compositions containing them. These compounds are particularly useful for the treatment of cancer.

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Laurence Lesuer-Ginot et al Cancer research vol. 59, pp. 2939-2943 1999.
Christain Bailly et al , Biochemistry 1999, vol. 38 pp. 15556-15563. Homocamptothecin , an E-ring . . . .
Lavergne et al, “An E-Ring . . . Activities”, Bioorg. Med. Chem. Letters, vol. 7, no 17, 1997, pp. 2235-2238.
Ejima et al, “Antitumor . . . Analogues”, Chemical and Pharm-aceutical Bulletin, vol. 40, no 3, Mar. 1, 1992, pp. 683-688.

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