Optically active (R)-(E)-(4-substituted-phenyl-1,3-dithiolan-2-y

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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5483151, A61K 314178, C07D40906

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active

06127397&

ABSTRACT:
An optically active (R)-(E)-(4-substituted-phenyl-1,3-dithiolan-2-ylidene)-1-imidazolylacetoni trile derivative represented by the following formula (I) or a salt thereof: ##STR1## wherein X represents 1 to 5 substituents which are the same or different and are selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group and a haloalkoxy group, provided that X does not represent a 2-chloro group or a 2,4-dichloro group; an antifungal composition comprising the same; and a process for producing the same.

REFERENCES:
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patent: 4738976 (1988-04-01), Seo et al.
patent: 5900488 (1999-05-01), Kodama
European Patent Office, Abstract of Japan (in English), No. 02275877, "Optically Active Ketene Dithiocetal Derivative And Its Production," publication date Nov. 9, 1990.
European Patent Office, Abstract of Japan (in English), No. 01242528, "Antifungal Agent For External Use," publication date Sep. 27, 1989.
European Patent Office, Abstract of Japan (in English), No. 62093227, "Antimycotic Agent," publication date Apr. 28, 1987.
European Patent Office, Abstract of Japan (in English), No. 62093204, "Non-Medical Fungicide And Production Thereof," publication date Apr. 28, 1987.

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