Optically active pyridonecarboxylic acid derivatives

Details Optically active pyridonecarboxylic acid derivatives Optically active pyridonecarboxylic acid derivatives

1993-10-28

1996-12-24

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514278, 540543, 540553, 540575, 540597, 546 15, 546123, 546156, 544231, 544363, C07D47104, C07D21556, A61K 3147, A61K 3144

Patent

active

055873863

ABSTRACT:
N.sub.1 -(1,2-cis-2-halogenocyclopropyl)-substituted pyridonecarboxylic acid derivatives represented by the following formula (I) the terms of which are defined in the specification and the salts thereof are disclosed: ##STR1## These compounds have patent antibacterial activities against a wide variety of infectious bacteria and are useful as antibacterial agents by oral or parenteral administration.

REFERENCES:
patent: 4705788 (1987-11-01), Schriewer
Kimura I Synthesis and Antibacterial Activity of N.sub.1 -2-Fluorocyclopropyl-4-Quinolone Derivatives, Research Institute, Daiichi Seiyaku Co., Ltd. 1987, Japan.
Kimura II Therapeutics in the 21st Century, The Japanese-United States Congress of Pharmaceutical Sciences, Dec. 2-7, 1987, Honolulu, Hawaii, Medicinal Chemistry, S156.

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