Optically active pyridobenzoxazine derivatives and anti-microbia

Details Optically active pyridobenzoxazine derivatives and anti-microbia Optically active pyridobenzoxazine derivatives and anti-microbia

1986-06-20

1991-10-01

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544101, A61K 31535, C07D49816

Patent

active

050534076

ABSTRACT:
An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses increased antimicrobial activity and reduced toxicity. The intermediate is useful for preparing such optically active pyridobenzoxazine derivatives such as Ofloxacin and anolog compounds.

REFERENCES:
patent: 4382892 (1983-05-01), Hayakawa et al.
Albrecht et al., Progress in Drug Research, vol. 21 (1971).
Rohlfing et al., J. Antibacterial Chemotherapy (1985).
Gerster et al., Proceedings of the North American Medicinal Chemistry Symposium, (1982).
Hayakawa et al., Chemical & Pharmaceutical Bulletin, vol. 32, No. 13, 1984, pp. 4907-4913, Tokyo, JP.
J. F. Gerster et al., J. Med. Chem., 1987, 30, 839.
Hayakawa et al., "Synthesis and Antibacterial Activities of Optically Active Ofloxacin", vol. 29, No. 1, Jan. 1986, pp. 163-164.

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