Optically active phenol derivatives and preparation thereof

Details Optically active phenol derivatives and preparation thereof Optically active phenol derivatives and preparation thereof

1994-06-27

1995-05-30

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

544171, 546225, 562455, 562463, 568716, 568717, 568743, 568766, 568780, C07C 3912, C07C 3914, C07C 3711

Patent

active

054203635

ABSTRACT:
An optically active tri-substituted methane compound having, as substituents, an aromatic ring group and a phenyl group having hydroxyl group at ortho or para position can be obtained by allowing a phenol compound unsubstituted at the ortho- or/and para-position to react with an optically active secondary carbinol compound having an aromatic ring group at the alpha-position in the presence of tri-substituted phosphine and diazodicarboxylate or diazodicarboxamide. These and other optically active tri-substituted methane compounds are useful as active ingredients for medicines or as intermediate compounds for preparing medicines.

REFERENCES:
patent: 2933523 (1960-04-01), Greenlee
patent: 3058946 (1962-10-01), Nametz
patent: 3471537 (1969-10-01), Berke
patent: 5162571 (1992-11-01), Shiraishi et al.
patent: 5354913 (1994-10-01), Shiraishi et al.
Mitsunbu, Synthesis, 1981 pp. 1-28.

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