Optically active nicotine analogs and process for their preparat

Details Optically active nicotine analogs and process for their preparat Optically active nicotine analogs and process for their preparat

1982-05-13

1984-06-05

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546282, C07D40104

Patent

active

044529848

ABSTRACT:
This invention provides a process for the preparation of cotinine and nicotine analogs containing substituents on pyrrolidinone/pyrrolidine ring at the 3' position of cotinine and at the 4' and 5' position of nicotine.
The process proceeds via a first step preparation of a cotinine intermediate which is represented by the formula: ##STR1## wherein M is an alkali metal cation.

REFERENCES:
Morrin et al., Chem. Abstracts, vol. 93, No. 13, Item 93-132, 669e, Sep. 29, 1980.
March, Advanced Organic Chemistry, Second Edition, pp. 108-111, McGraw-Hill Pub., 1977.
Hecht et al., Journal of Medicinal Chem., vol, 23, No. 10, pp. 1175-1178, Oct. 1980.
Castonguay et al., Journal of Organic Chem., vol. 44, No. 24, pp. 4332-4337, (1979).
Titus et al., Chemical Abstracts, vol. 76, No. 1, Item No. 1928q, Jan. 3, 1972.
Chemical Abstracts, Ninth Collective Index, vols. 76-85, Formulas C.sub.9 H.sub.13 BrS-C.sub.12 H.sub.10 N.sub.2 O.sub.2 Zr, (1976).

Affiliated with

Also associated with

Rating

Optically active nicotine analogs and process for their preparat does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optically active nicotine analogs and process for their preparat, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optically active nicotine analogs and process for their preparat will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1498587