Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-10-22
1977-05-03
Killos, Paul J.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2603409, 260474, 424308, C07C 6976
Patent
active
040214737
ABSTRACT:
New optically active esters of N,N'-dialkyl-N,N'-bis-(1-hydroxy-2-butyl)ethylenediamine and their salts, which shown antiarrhythmic, coronary and spasmolytic activity and a protective action in the case of myocardial infarcts corresponding to the formula: ##STR1## in which the R groups may be the same or different and R is a C.sub.n H.sub.2n.sub.+1 group wherein n = 1-4;
Ar denotes a phenyl group substituted in positions 3,4 by --OCH.sub.3, --0CH.sub.2 O-- or --OC.sub.2 H.sub.5 groups or in positions 3, 4, 5 by --OCH.sub.3 or --OC.sub.2 H.sub.5 groups;
A denotes the anion of a hydrohalic acid, sulfuric acid, and aryl or alkyl carboxylic or sulfonic acid, wherein the aryl group is phenyl, o-or p-tolyl, o-or p-hydroxyphenyl, o-or p-aminophenyl or naphthyl and the alkyl group has from 1 to 4 carbon atoms.
REFERENCES:
Jenkins et al., "The Chemistry of Organic Medicinal Products," Wiley & Sons, Inc., N.Y., (1957), pp. 465-468.
Willianson et al., C.A. 57, 16400g, (1962).
Shepherd et al., C.A. 58, 13774f-13775g, (1963).
Societa Farmaceutici Italia, C.A. 75, 63110e, (1971).
Eckstein Marian
Herdegen Eleonora
Kulig Daniel
May Jerzy
Killos Paul J.
Krakowskie Zaklady Farmaceuticzne "Polfa"
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